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Genetics of Susceptibility to Mouse Skin Tumor Promotion

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Book cover The Pathobiology of Neoplasia

Abstract

The protocol used in most two-stage carcinogenesis studies in mouse skin was first described by Mottram1 and forms the basis of the operational criteria defining a promoter. Mottram elicited skin tumors by treating the backs of mice with a single subcarcinogenic dose of the polycyclic aromatic hydrocarbon (PAH) benzo(a)pyrene [B(a)P], followed by repeated applications of croton oil, obtained from the seeds of Crown tiglium. Subsequently, the most active tumor-promoting component of croton oil was identified as the phorbol diester, 12-O-tetradecanoyl-phorbol-13-acetate (TPA),2–5 and today it is the most frequently used promoter for mechanistic studies.

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  1. Science Park, Research Division, The University of Texas System Cancer Center, Smithville, Texas, 78957, USA

    John DiGiovanni

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  1. Department of Pathology, Medical of College of Virginia, Virginia Commonwealth University, 23298, Richmond, Virginia, USA

    Alphonse E. Sirica

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DiGiovanni, J. (1989). Genetics of Susceptibility to Mouse Skin Tumor Promotion. In: Sirica, A.E. (eds) The Pathobiology of Neoplasia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5523-6_13

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