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Basic and Clinical Aspects of Growth Hormone pp 233–249Cite as

Insulin-Like Growth Factors in Fetal Growth

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Part of the book series: Serono Symposia, USA ((SERONOSYMP))

Abstract

The insulin-like growth factors, IGF-I and IGF-II, are single-chain polypeptides chemically related to insulin that are synthesized in multiple fetal and adult tissues, and stimulate DMA synthesis and cell differentiation (1,2). IGF-I is regulated by growth hormone and nutritional factors, and promotes bone elongation in childhood (2). Based on results initially obtained in rats, IGF-II was proposed to play a role in fetal growth and development. This paper will review some of the evidence in support of this hypothesis, and discuss its applicability to human fetal development.

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Authors and Affiliations

  1. National Institutes of Health, Bethesda, MD, 20892, USA

    Matthew M. Rechler, Yvonne W-H. Yang, Alexandra L. Brown, Joyce A. Romanus, Sallie O. Adams, Wieland Kiess & S. Peter Nissley

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  1. Matthew M. Rechler
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  2. Yvonne W-H. Yang
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  3. Alexandra L. Brown
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  4. Joyce A. Romanus
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  5. Sallie O. Adams
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  6. Wieland Kiess
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  1. University of South Florida, Tampa, Florida, USA

    Barry B. Bercu

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© 1988 Plenum Press, New York

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Rechler, M.M. et al. (1988). Insulin-Like Growth Factors in Fetal Growth. In: Bercu, B.B. (eds) Basic and Clinical Aspects of Growth Hormone. Serono Symposia, USA. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5505-2_21

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  • DOI: https://doi.org/10.1007/978-1-4684-5505-2_21

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