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Biological Action of Insulin-Like Growth Factor-I In Vivo

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Basic and Clinical Aspects of Growth Hormone

Part of the book series: Serono Symposia, USA ((SERONOSYMP))

Abstract

It has been well known that somatomedin-C/insulin-like growth factor-I (SmC/IGF-I) stimulates cell proliferation and cell differentiation and an insulin-like action in vitro (1). However, there have been only a few reports on the effects of SmC/IGF-I in vivo because of scarcity of pure extracted SmC/IGF-I (2–4). Recently, insulin-like growth factor-I (IGF-I) has been synthesized by recombinant DNA technology (5–7). With the availability of large quantities of the biosynthetic IGF-I, the biological effects of IGF-I in vivo in rats have been studied (8–12). In this paper, the results of our study for biological action of IGF-I in vivo are reported.

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References

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Authors and Affiliations

  1. Department of Medicine, Institute of Clinical Endocrinology, Tokyo Women’s Medical College, Tokyo, 162, Japan

    Naomi Hizuka, Kazue Takano, Kumiko Asakawa, Izumi Sukegawa, Reiko Horikawa & Kazuo Shizume

  2. Research Laboratory, The Foundation for Growth Science, Tokyo, 162, Japan

    Naomi Hizuka, Kazue Takano, Kumiko Asakawa, Izumi Sukegawa, Reiko Horikawa & Kazuo Shizume

  3. Fujisawa Pharmaceutical Co., Osaka, 532, Japan

    Hiroyuki Kikuchi

Authors
  1. Naomi Hizuka
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  2. Kazue Takano
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  3. Kumiko Asakawa
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  4. Izumi Sukegawa
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  5. Reiko Horikawa
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  6. Hiroyuki Kikuchi
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  7. Kazuo Shizume
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Editor information

Editors and Affiliations

  1. University of South Florida, Tampa, Florida, USA

    Barry B. Bercu

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© 1988 Plenum Press, New York

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Hizuka, N. et al. (1988). Biological Action of Insulin-Like Growth Factor-I In Vivo. In: Bercu, B.B. (eds) Basic and Clinical Aspects of Growth Hormone. Serono Symposia, USA. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5505-2_20

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  • DOI: https://doi.org/10.1007/978-1-4684-5505-2_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5507-6

  • Online ISBN: 978-1-4684-5505-2

  • eBook Packages: Springer Book Archive

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