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Growth Hormone Neurosecretory Dysfunction: Update

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Basic and Clinical Aspects of Growth Hormone

Part of the book series: Serono Symposia, USA ((SERONOSYMP))

Abstract

The neuroregulation of GH secretion is complex involving the dual regulatory control of a GH releasing hormone (GHRH) and GH inhibiting hormone (somatostatin or SRIH) (see Figures 1 and 2). These neurohormones are further regulated by neurotransmitters (Fig. 1). Experimental evidence (animal and human) for anatomic distribution and the possible role of neurotransmitters (dopaminergic, catecholaminergic, cholinergic, serotonergic, histaminergic, gama-aminobutyric acidergic) are reviewed in greater detail elsewhere (1,2). We hypothesize that defects in the neuro- regulatory control of GH secretion results in decreased or disordered GH secretion which is, ultimately, expressed as poor growth velocity and short stature.

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Authors and Affiliations

  1. Department of Pediatrics, University of South Florida College of Medicine, Tampa, USA

    Barry B. Bercu M.D.

  2. All Children’s Hospital, St. Petersburg, Florida, 33731, USA

    Barry B. Bercu M.D.

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  1. Barry B. Bercu M.D.
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Editors and Affiliations

  1. University of South Florida, Tampa, Florida, USA

    Barry B. Bercu

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© 1988 Plenum Press, New York

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Bercu, B.B. (1988). Growth Hormone Neurosecretory Dysfunction: Update. In: Bercu, B.B. (eds) Basic and Clinical Aspects of Growth Hormone. Serono Symposia, USA. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5505-2_12

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  • DOI: https://doi.org/10.1007/978-1-4684-5505-2_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5507-6

  • Online ISBN: 978-1-4684-5505-2

  • eBook Packages: Springer Book Archive

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