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Modulation of the Respiratory Burst by Naturally Occurring Substances

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The Respiratory Burst and Its Physiological Significance

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Abstract

The respiratory burst and subsequent production of oxygen radicals and metabolites by the leukocyte are considered important contributing processes in nonspecific microbicidal systems.1 In addition, in disease states in which inflammation, tissue destruction, and the apparent absence of bacterial invasion are predominant features, excessive and inappropriate production of oxygen radicals and metabolites is thought to play a substantial role in continuing tissue destruction.2 Despite a lack of substantial direct evidence for a primary role, there is nonetheless much indirect evidence incriminating oxygen metabolites as playing a major contributing role in inflammation.2 Oxygen radicals have been strongly implicated as pathogenic in a wide variety of inflammatory disease states involving most physiological organ systems.3

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Author information

Authors and Affiliations

  1. Division of Clinical Immunology and Allergy, The Montreal General Hospital, Montreal, Québec, H3G 1A4, Canada

    Stanley D. Somerfield & Emil Skamene

Authors
  1. Stanley D. Somerfield
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  2. Emil Skamene
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Editor information

Editors and Affiliations

  1. St. Margaret’s Hospital for Women, Boston, Massachusetts, USA

    Anthony J. Sbarra

  2. Tufts University School of Medicine, Boston, Massachusetts, USA

    Anthony J. Sbarra

  3. Clinical Pathology Facility, Inc., Pittsburgh, Pennsylvania, USA

    Robert R. Strauss

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© 1988 Plenum Press, New York

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Somerfield, S.D., Skamene, E. (1988). Modulation of the Respiratory Burst by Naturally Occurring Substances. In: Sbarra, A.J., Strauss, R.R. (eds) The Respiratory Burst and Its Physiological Significance. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5496-3_9

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  • DOI: https://doi.org/10.1007/978-1-4684-5496-3_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5498-7

  • Online ISBN: 978-1-4684-5496-3

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