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The Respiratory Burst and Endothelial Cells

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The Respiratory Burst and Its Physiological Significance

Abstract

Neutrophils are the first-line defense of the host against foreign invaders once they have reached the tissues. When at work, however, the neutrophils behave as a double-edged sword. In fact, the reactive oxygen intermediates (ROI) generated by the respiratory burst and the granular components released during degranulation contribute to killing of ingested microorganisms on one side, but, on the other they may damage tissues in both their cellular and extracellular components. Several cell types, including the neutrophils themselves, may be the target of ROI produced by the neutrophil respiratory burst.1 Endothelial cells, a crucial cell type in the interface phenomena between blood and tissues, are among those targets. This chapter first reviews evidence, from both in vitro and in vivo studies, of the involvement of the neutrophil respiratory burst in endothelial cell damage, followed by a discussion of the possible role of such a damage in human pathology.

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Authors and Affiliations

  1. Institute of General Pathology, University of Trieste, 34127, Trieste, Italy

    Aldo Dobrina & Pierluigi Patriarca

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  1. Aldo Dobrina
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  2. Pierluigi Patriarca
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Editors and Affiliations

  1. St. Margaret’s Hospital for Women, Boston, Massachusetts, USA

    Anthony J. Sbarra

  2. Tufts University School of Medicine, Boston, Massachusetts, USA

    Anthony J. Sbarra

  3. Clinical Pathology Facility, Inc., Pittsburgh, Pennsylvania, USA

    Robert R. Strauss

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© 1988 Plenum Press, New York

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Dobrina, A., Patriarca, P. (1988). The Respiratory Burst and Endothelial Cells. In: Sbarra, A.J., Strauss, R.R. (eds) The Respiratory Burst and Its Physiological Significance. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5496-3_6

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  • DOI: https://doi.org/10.1007/978-1-4684-5496-3_6

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  • Print ISBN: 978-1-4684-5498-7

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