Abstract
When phagocytic leukocytes are activated to kill microorganisms, these cells respond with considerable changes in their cellular metabolism and structure.1 Most marked is a 20- to 30-fold increase in the oxygen consumption (i.e., the respiratory burst) that is not sensitive to inhibitors of the mitochondrial respiration.2 The extra oxygen consumption reflects the action of a phagocyte-specific oxidase, responsible for the generation of reduced oxygen species.1 This enzyme is localized in the plasma membrane and—after phagocytosis—in the phagosomal membranes of the cell.3,4
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© 1988 Plenum Press, New York
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Roos, D., Lutter, R., Bolscher, B.G.J.M. (1988). The Respiratory Burst and the NADPH Oxidase of Phagocytic Leukocytes. In: Sbarra, A.J., Strauss, R.R. (eds) The Respiratory Burst and Its Physiological Significance. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5496-3_3
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