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The Respiratory Burst and Aging

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The Respiratory Burst and Its Physiological Significance

Abstract

When exposed to certain stimuli, phagocytic cells (neutrophils and mononuclear phagocytes) undergo marked changes in the way they handle oxygen.1 Their rates of oxygen uptake increase greatly, they begin to produce large amounts of superoxide (O −2 ) and hydrogen peroxide (H2O2), and they begin to metabolize large quantities of glucose by way of the hexose monophosphate shunt. Because of the sharp increase in oxygen uptake, this series of changes has come to be known as the respiratory burst. Its purpose is to generate powerful microbicidal agents by the partial reduction of oxygen.

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Authors and Affiliations

  1. First Department of Medicine, University Medical School, 4012, Debrecen, Hungary

    Tamás Fülöp Jr., Gabriella Fóris, József T. Nagy, Zsuzsa Varga & András Leövey

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  1. Tamás Fülöp Jr.
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  2. Gabriella Fóris
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  3. József T. Nagy
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  4. Zsuzsa Varga
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  5. András Leövey
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Editors and Affiliations

  1. St. Margaret’s Hospital for Women, Boston, Massachusetts, USA

    Anthony J. Sbarra

  2. Tufts University School of Medicine, Boston, Massachusetts, USA

    Anthony J. Sbarra

  3. Clinical Pathology Facility, Inc., Pittsburgh, Pennsylvania, USA

    Robert R. Strauss

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© 1988 Plenum Press, New York

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Fülöp, T., Fóris, G., Nagy, J.T., Varga, Z., Leövey, A. (1988). The Respiratory Burst and Aging. In: Sbarra, A.J., Strauss, R.R. (eds) The Respiratory Burst and Its Physiological Significance. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5496-3_20

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  • DOI: https://doi.org/10.1007/978-1-4684-5496-3_20

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