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The Respiratory Burst of Phagocytes

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The Respiratory Burst and Its Physiological Significance

Abstract

Studies on the oxygen metabolism of phagocytes began in 1933 with the observation that during phagoytosis, white blood cells (WBC) undergo a striking increase in oxygen consumption.1,2 These observations did not attract much attention until the 1950s, when the metabolic activities of neutrophils during phagocytosis of foreign matter were reinvestigated.3–7 The key initial observations that led to further research in the field were that (1) stimulated oxygen consumption is accompanied by enhanced catabolism of glucose through the hexose monophosphate shunt,4, 6 (2) inhibitors of mitochondrial oxidative respiration do not block oxygen consumption,5,6 and (3) hydrogen peroxide is produced in parallel.8,9

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Authors and Affiliations

  1. Institute of General Pathology, University of Verona, 37134, Verona, Italy

    Giorgio Berton, Stefano Dusi & Paolo Bellavite

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  1. Giorgio Berton
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  2. Stefano Dusi
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  3. Paolo Bellavite
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  1. St. Margaret’s Hospital for Women, Boston, Massachusetts, USA

    Anthony J. Sbarra

  2. Tufts University School of Medicine, Boston, Massachusetts, USA

    Anthony J. Sbarra

  3. Clinical Pathology Facility, Inc., Pittsburgh, Pennsylvania, USA

    Robert R. Strauss

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© 1988 Plenum Press, New York

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Berton, G., Dusi, S., Bellavite, P. (1988). The Respiratory Burst of Phagocytes. In: Sbarra, A.J., Strauss, R.R. (eds) The Respiratory Burst and Its Physiological Significance. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5496-3_2

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  • DOI: https://doi.org/10.1007/978-1-4684-5496-3_2

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