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Drug-Induced Agranulocytosis and Other Effects Mediated by Peroxidases during the Respiratory Burst

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The Respiratory Burst and Its Physiological Significance

Abstract

There are numerous examples demonstrating strong evidence that toxic reactions to drugs or other chemicals are due to chemically reactive metabolites.1 The form this toxicity takes can vary from cancer (presumably due to reaction of the metabolite with DNA) to anaphylactic reactions [presumably due to the metabolite acting as a hapten and reacting with a protein leading to the induction of immunoglobulin E (IgE) antibodies]. The greatest activity of enzymes capable of metabolizing xenobiotics is found in the liver; however, such enzymatic activity has been found in numerous other organs. One important aspect of this extrahepatic activity is that most reactive metabolites formed in the liver are too reactive to reach other target organs.

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Authors and Affiliations

  1. Faculties of Pharmacy and Medicine, University of Toronto and Sunnybrook Hospital, Toronto, Ontario, M5S 1A1, Canada

    Jack P. Uetrecht

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  1. Jack P. Uetrecht
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Editors and Affiliations

  1. St. Margaret’s Hospital for Women, Boston, Massachusetts, USA

    Anthony J. Sbarra

  2. Tufts University School of Medicine, Boston, Massachusetts, USA

    Anthony J. Sbarra

  3. Clinical Pathology Facility, Inc., Pittsburgh, Pennsylvania, USA

    Robert R. Strauss

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© 1988 Plenum Press, New York

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Uetrecht, J.P. (1988). Drug-Induced Agranulocytosis and Other Effects Mediated by Peroxidases during the Respiratory Burst. In: Sbarra, A.J., Strauss, R.R. (eds) The Respiratory Burst and Its Physiological Significance. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5496-3_11

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  • DOI: https://doi.org/10.1007/978-1-4684-5496-3_11

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