Fragile Sites, Mutagens and Genomic Rearrangements in Cancer

  • Jorge J. Yunis
Part of the Basic Life Sciences book series (BLSC, volume 43)


The finding of specific genomic rearrangements in human cancer over the past several years is having important biologic implications. Although the genomic mechanisms involved in these rearrangements for the most part remain to be elucidated, critical clues are being uncovered in a number of different malignancies.


Acute Lymphocytic Leukemia Mycosis Fungoides Fragile Site Prolymphocytic Leukemia Chromosome Defect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. Boles, T.C., and Hogan, M.E., 1986, High-resolution mapping of carcinogen binding sites on DNA, Biochem., 25:3039.CrossRefGoogle Scholar
  2. Cavenee, W., Dryja, T.P., Phillips, R.A., Benedict, W.F., Godbout, R., Gallie, B.L., Murphree, A.L., Strong, L.C., and White, R.L., 1983, Expression of recessive alleles by chromosomal mechanisms in retinoblastoma, Nature, 305:779.PubMedCrossRefGoogle Scholar
  3. Friend, S.H., Bernards, R., Rogelj, S., Weinberg, R.A., Rapaport, J.M., Albert, D.M., and Dryja, T.P., 1986, A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma, Nature, 323:643.PubMedCrossRefGoogle Scholar
  4. IARC monographs on the evaluation of the carcinogenic risk of chemicals to human, 1986, Tobacco smoking. Vol. 38, IARC, Lyon, France.Google Scholar
  5. IARC monographs on the evolution of carcinogenic risk of chemicals to humans, suppl. 4, 1982, IARC, Lyon, France.Google Scholar
  6. Ishii, S., Merlino, G.T., and Pastan, I., 1985, Promoter region of the human Harvey ras proto-oncogene: similarity to the EGF receptor proto-oncogene promoter, Science, 230:1378.PubMedCrossRefGoogle Scholar
  7. Kohwi-Shigematsu, T., Gelinas, R., and Weintraub, H., 1983, Detection of an altered DNA conformation at specific sites in chromatin and supercoiled DNA, Proc. Natl. Acad. Sci. U.S.A., 80:4389.PubMedCrossRefGoogle Scholar
  8. Lee, W.H., Bookstein, R., Hong, F., Young, L-J., Shew, J-Y, and Lee, Y.H-P., 1987, Human retinoblastoma susceptibility gene: cloning, identification, and sequence, Science, 235:1394.PubMedCrossRefGoogle Scholar
  9. Lee, W.H., Murphree, A.L., and Benedict, W.F., Expression and amplification of the N-myc gene in primary retinoblastoma, Nature, 309:458.Google Scholar
  10. Mattes, W.B., Hartley, J.A., and Kohn, K.W., 1986, DNA sequence selectivity of guanine-N7 alkylation by nitrogen mustards, Nucleic Acids Res., 14:2971.PubMedCrossRefGoogle Scholar
  11. Merletti, F., Heseltine, E., Saracci, R., Simonato, L., Vainio, H., and Wilbourn, J., 1984, Target organs for carcinogenicity of chemicals and industrial exposures in humans: A review of results in the IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, Cancer Res., 44:2244.PubMedGoogle Scholar
  12. Pogosianz, H.E., and Kuznetsova, L.E., 1986, Nonrandom chromosomal changes in retinoblastomas, Arch. Geschwulstforsch., 56:135.PubMedGoogle Scholar
  13. Popescu, N.C., Amsbaugh, S.C., and DiPaolo, J.A., 1987, Human papillomavirus type 18 DNA is integrated at a single chromosome site in cervical carcinoma cell line SW 756, J.Virol., 51:1682.Google Scholar
  14. Popescu, N.C., DiPaolo, J.A., and Amsbaugh, S.C., 1987, Integration sites of human papillomavirus 18 DNA sequences on HeLa cell chromosomes, Cytogenet. Cell Genet., 44:58.PubMedCrossRefGoogle Scholar
  15. Raizis, A.M., Becroft, D.M., Shaw, R.L., and Reeve, A.E., 1985, A mitotic recombination in Wilms tumor occurs between the parathyroid hormone locus and llpl3, Hum. Genet., 70:344.PubMedCrossRefGoogle Scholar
  16. Robinson, H.L., and Gagnon, G.C., 1986, Patterns of proviral insertion and deletion in avian leukosis virus-induced lymphomas, J. Virol., 57:28.PubMedGoogle Scholar
  17. Rogers, J., 1983, CACA sequence—the ends and the means? Nature, 305:101.PubMedCrossRefGoogle Scholar
  18. Sheffrey, M., 1986, Chromatin structure, gene expression and differentiation, in: M. Risley, ed. “Chromosome Structure and Function,” Van Nostrand Reinhold Co., New York, pp. 39–91.Google Scholar
  19. Squire, J., Phillip, R.A., Boyce, L., Godbout, R., Rogers, B., and Gallie, B., 1984, Iso-chromosome 6p, a unique chromosomal abnormality in retinoblastoma: Verification by standard staining techniques, new densitometric methods, and somatic cell hybridization, Hum. Genet., 66:46.PubMedCrossRefGoogle Scholar
  20. Vijaya, S., Steffen, D.L., and Robinson, H.L., 1986, Acceptor sites for retroviral integrations map near DNase I-hypersensitive sites in chromatin, J. Virol., 60:683.PubMedGoogle Scholar
  21. Whang-Peng, J., Kao-Shan, C.S., Lee, E.C., Bunn, P.A., Carney, D.N., Gazdar, A.F., and Minna, J.D., 1982, Specific chromosome defect associated with human small-cell lung cancer: deletion 3p(14–23), Science, 215:181.PubMedCrossRefGoogle Scholar
  22. Yunis, J.J., 1983, The chromosomal basis of human neoplasia, Science, 221:227.PubMedCrossRefGoogle Scholar
  23. Yunis J.J., 1984, Fragile sites and predisposition to leukemia and lymphoma, Cancer Genet. Cytogenet., 12:85.PubMedCrossRefGoogle Scholar
  24. Yunis, J.J., 1986, Chromosomal rearrangements, genes, and fragile sites in cancer: Clinical and biologic implications, in: “Important Advances in Oncology 1986,” V. DeVita, S. Hellman, and S. Rosenberg, eds. J.B. Lippincott, Philadelphia, pp. 93–128.Google Scholar
  25. Yunis, J.J., 1987, Multiple recurrent genomic deletions and duplications are a common feature in most human neoplasias, UCLA Symposium: Recent advances in leukemia and lymphoma, R.P. Gale and D.W. Golde, eds, Alan R. Liss, Inc., New York.Google Scholar
  26. Yunis, J.J., Frizzera, G., Oken, M.M., McKenna, J., Theologides, A., and Arnesen, M., 1987a, Multiple reçurent genomic defects in follicular lymphoma: A possible model for cancer, N. Engl. J. Med., 316:79.PubMedCrossRefGoogle Scholar
  27. Yunis, J.J., and Ramsay, N.K.C., 1978, Retinoblastoma and subband deletion of chromosome 13, Am. J. Dis. Child., 132:161.PubMedGoogle Scholar
  28. Yunis, J.J., and Ramsay N.K.C., 1980, Familial occurrence of aniridia—Wilms’ tumor syndrome with deletion 11p13–14.1, J. Pediatr., 96:1027.PubMedCrossRefGoogle Scholar
  29. Yunis, J.J., and Soreng, A.L., 1984, Constitutive fragile sites and cancer, Science, 226:1199.PubMedCrossRefGoogle Scholar
  30. Yunis, J.J., Soreng, A.L., and Bowe, A.E., 1987b, Fragile sites are targets of diverse mutagens and carcinogens, Oncogene, 1:59.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Jorge J. Yunis
    • 1
  1. 1.Department of Laboratory Medicine and PathologyUniversity of Minnesota Medical SchoolMinneapolisUSA

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