Variability in Life Span Functional Capacity

  • David W. E. Smith
Part of the Basic Life Sciences book series (BLSC, volume 43)


Aging is a process in which both risk and phenotypic variability have important roles and significant interactions. Other contributions to this volume include examples of age as a determinant of responses to environmental challenges and examples in which variations in longevity are the ultimate consequence of phenotypic variability.


Cardiac Output Glomerular Filtration Rate Leydig Cell Phenotypic Variability Functional Reserve 
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  1. 1.
    L. Rosentstein, and E. Berman, Postnatal body weight changes of domestic cats maintained in an outdoor colony, Am. J. Veterinary Res. 34: 575 (1973).Google Scholar
  2. 2.
    C.E. Finch, and L. Hayflick, “Handbook of the Biology of Aging,” Van Nostrand Reinhold Company, New York (1977).Google Scholar
  3. 3.
    C.E. Finch, and E.L. Schneider, “Handbook of the Biology of Aging,” Second Edition, Van Nostrand Reinhold Company, New York (1985).Google Scholar
  4. 4.
    E.J. Masoro, “Handbook of Physiology in Aging,” CRC Press, Boca Ratan (1981).Google Scholar
  5. 5.
    M. Landowne, M. Brandfonbrenner and N.W. Shock, The relation of age to certain measures of performance of the heart and circulation, Circulation 12: 567 (1955).PubMedGoogle Scholar
  6. 6.
    W.E. Miall, and H.G. Lovell, Relation between change of blood pressure and age, Brit. Med. J. 2: 600 (1967).CrossRefGoogle Scholar
  7. 7.
    L.G. Wesson, “Physiology of the human kidney,” Grune and Stratton, New York (1969).Google Scholar
  8. 8.
    H.W. Shock, Physiological aspects of aging in man, Ann. Rev. Physiol. 23: 97 (1961).CrossRefGoogle Scholar
  9. 9.
    M. Brandfonbrenner, M. Landowne, and N.W. Shock, Changes in cardiac output with age, Circulation 12: 557 (1955).Google Scholar
  10. 10.
    M.R. Becklake, F.G.R. Dagenaic, G.L. Ostiguy and C.A. Guzman, Influence of age and sex on exercise cardiac output, J. Appl. Physiol. 20: 938 (1965).PubMedGoogle Scholar
  11. 11.
    K.M. Pirke and P. Doerr, Age realted changes in free plasma testosterone, dihydrotestosterone, and oestradiol, Acta. Endocrinol. 80: 171 (1975).PubMedGoogle Scholar
  12. 12.
    C.E. Finch, J.R. Foster and A.E. Mirsky, Aging and the regulation of cell activities during exposure to cold, J. Gen. Physiol. 54: 690 (1969).PubMedCrossRefGoogle Scholar
  13. 13.
    B. Grad and V.A. Kral, Response of young and old mice to cold, J. Geront. 12: 172 (1957).PubMedGoogle Scholar
  14. 14.
    W.R. Hazard, Biological basis of the sex differential in longevity, J. Am. Geriatrics Soc. 34: 455 (1986).Google Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • David W. E. Smith
    • 1
    • 2
  1. 1.National Institute on AgingNational Institutes of HealthBethesdaUSA
  2. 2.Northwestern University Medical SchoolChicagoUSA

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