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Gene-Environmental Interaction as a Cause of Human Variation

  • H. Eldon Sutton
Chapter
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Part of the Basic Life Sciences book series (BLSC, volume 43)

Abstract

To Mendel has often been attributed the good luck or good judgment of choosing for study traits that were clearly alternative characters and that were free of environmental influence. Galton, on the other hand, studied characteristics that were complex and that often had the potential for alteration by the environment, so-called multifactorial traits. The Galtonian approach, although it uses ever more sophisticated statistical and computational tools, has provided little insight into the mode of action of individual genes. It has, of course, been useful in plant and animal breeding experiments to study the contributions of both genetic and environmental variation and, as we have heard at this symposium, may help us to estimate inherited risk.

Keywords

Megaloblastic Anemia Pyridoxal Phosphate Hypoxanthine Phosphoribosyl Transferase Sodium Cyanoborohydride Propionic Acidemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Finkelstein, J. D., and Chalmers, F. T., 1970, Pyridoxine effects on cystathionine synthase in rat liver, J. Nutr., 100:467–469.PubMedGoogle Scholar
  2. Goldman, D., and Merrill, C. R., 1983, Human lymphocyte polymorphisms detected by quantitative two-dimensional electrophoresis, Am. J. Hum. Genet., 35:827–837.PubMedGoogle Scholar
  3. Harris, H., 1980, The Principles of Human Biochemical Genetics, 3rd ed. Elsevier/North-Holland, New York.Google Scholar
  4. Jentoft, N., and Dearborn, D. G., 1979, Labeling of proteins by reductive methylation using sodium cyanoborohydride. J. Biol. Chem., 254: 4359–4365.PubMedGoogle Scholar
  5. Lui, A., and Lumeng, L., 1986, Pharmacology and therapeutic usage of vitamin B6, in: Vitamin B 6 Pyridoxal Phosphate: Chemical, Biochemical, and Medical Aspects, Part B (D. Dolphin, R. Poulson, and O. Avramovic, eds.), John Wiley & Sons, New York, pp. 601–674.Google Scholar
  6. Sturman, J. A., 1986, Vitamin B6 and sulfur amino acid metabolism, inborn errors, brain function, and megavitamin therapy, in: Vitamin B 6 Pyridoxal Phosphate: Chemical, Biochemical, and Medical Aspects, Part B (D. Dolphin, R. Poulson, and O. Avramovic, eds.), John Wiley & Sons, New York, pp. 507–572.Google Scholar
  7. Takahashi, N., Neel, J. V., Nagahata-Shimoichi, Y., Asakawa, J., Tanaka, Y., and Satoh, C., 1986, Inherited electrophoretic variants detected in a Japanese population with two-dimensional gels of erythrocyte lysates, Ann. Hum. Genet., 50:313–325.PubMedCrossRefGoogle Scholar
  8. Williams, R. J., Berry, L. J., and Beerstecher, E. Jr., 1949, Individual metabolic patterns, alcoholism, genetotrophic diseases, Proc. Natl. Acad. Sci. (U.S.), 35:265–271.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • H. Eldon Sutton
    • 1
  1. 1.Genetics Institute and Department of ZoologyThe University of Texas at AustinAustinUSA

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