Abstract
In 1678, Antony Van Leeuwenhoek described the deposition of colorless crystals, later to be identified as spermine (SPM) phosphate, in seminal fluid. SPM is one of the aliphatic cations called polyamines (PAs) found in all living things. (See Table 1) The diamine putrescine (PTC) proved to be an essential growth factor for mutant Hemophilus parainfluenza. In mammals, increased biosynthesis of PAs, including spermidine (SPD), was detected during both normal and pathological tissue growth. Increased amount of SPM, SPD, and PTC were found in blood and urine under these circumstances. The nature and regulatory functions of PAs and the enzymes controlling their production and metabolic degradation are beginning to be understood.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Koenig, H., Goldstone, A. D., Iqbal, Z., Fan, C.-C., Lu, C. Y., Trout, J.J., Rapid polyamine synthesis plays a key role in the mediation of receptor- and voltage-regulated calcium fluxes. In Recent Progress in Polyamine Research, L. Selmeci, et al, Eds, Akademiai Kiado, Budapest, 1985, 191–201.
Canellakis, E. S., Heller, J. S., Kyriakidis, D. A., The interation of ornithine decarboxylase with its antizjone. In Advances in Polyamine Research, Vol. 3, C M Caldarera et al Eds, Raven Press, New York, 1981, 1–13.
Abraham, A. K., Olsnes, S., Pihl, A., Fidelity of protein synthesis in vitro is increased in the presence of spermidine. FEBS Lett, 101:93–96, 1979.
Patt, L. M., Barrantes, D. M., Gleisner, J. M., Houck, J. C., Abnormal behavior of polyamines on gel filtration: a cautionary note. Cell Biology Int Reports, 5(8):798–803, 1981.
Radtke, H. W., Rege, A. B., LaMarche, M. B., Bartos, D., Bartos, F., Campbell, R. A., Identification of spermine as an inhibitor of erythropoiesis in patients with chronic renal failure. J Clin Invest, 67:1623–1629, 1981.
Byrd, W. J., Jacobs, D. M., Amoss, M. S., Influence of synthetic polyamines on in vitro responses of immunocompetent cells. In Advances in Polyamine Research, Vol 2, R.A. Campbell, et al, Eds, Raven Press, New York, 1978, 71–83.
Ferrante, A., Inhibition of human neutrophil locomotion by the polyamine oxidase-polyamine system. Immunology 54:785–790, 1985.
Caldarera, C. M., Tantini, B., Marmiroli, S., Pignatti, C., Clô, C., Polyamine control of cellular cycle nucleotide response. In Recent Progress in Polyamine Research, L. Selmeci, et al, Eds, Akademiai Kiado, Budapest, 1985, 109–118.
Campbell, R. A., LaBerge, T., Campbell-Boswell, M., Brooks, R. E., Talwalkar, Y. B., Myeloid body formation under conditions of polyamine stress. In Advances in Polyamine Research, Vol 4, U. Bachrach, et al, Eds, Raven Press, New York, 1983, 107–125.
Bagdade, J., Campbell, R., Grettie, D., Bartos, D., Bartos, F., Effects of polyamines on human arterial smooth muscle cells in tissue culture. In Advances in Polyamine Research, Vol 2, RA Campbell, et al, Eds, Raven Press, New York, 1978, 345–349.
Campbell, R. A. Unpublished observations, 1986.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Plenum Press, New York
About this chapter
Cite this chapter
Campbell, R.A. (1987). Polyamines and Uremia. In: Ringoir, S., Vanholder, R., Massry, S.G. (eds) Uremic Toxins. Advances in Experimental Medicine and Biology, vol 223. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5445-1_6
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5445-1_6
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5447-5
Online ISBN: 978-1-4684-5445-1
eBook Packages: Springer Book Archive