Abstract
From numerous of publications it is evident that an immunodeficiency exists in end-stage renal failure (ESRF) patients. To give a strict definition of these defects is, however, difficult.
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References
R.J. Glassock, Nutrition, immunology, and renal disease, Kidney Int. 26;Suppl. 16:194 (1985).
G.J. Laundy, and B.A. Bradley, Immunoglobulin allotypes in patients in end-stage renal failure, J Immunogenetics 12:181 (1985).
R.F. Gagnon, J. Shuster, M. Kaye, Auto-immunity in patients with end-stage renal disease maintained on hemodialysis and continuous ambulatory peritoneal dialysis, J Clin Lab Immunol. 11:155 (1983).
M.A. Watson, J.D. Briggs, A.A. Diamandopoulous, D.N.H. Hamilton and H.M. Dick, Endogenous cell-mediated immunity, blood transfusion and outcome of renal transplantation, Lancet. 1:1323 (1979).
A.K. Cheung, and L.W. Henderson, Effects of complement activation by hemodialysis membranes. Am J Nephrol. 6: 81 (1986).
D.A. Casciato, L.P. McAdam, J.D. Kopple, R. Bluestone, L.S. Goldberg, P.J. Clements, and B.W. Knutson, Immunologic abnormalities in hemodialysis patients; Improvement after Pyridoxin therapy, Nephron. 38:9 (1984).
L.D. Antoniou, and R.J. Shalhoub, Zinc-induced enhance ment of lymphocyte function and viability in chronic uremia. Nephron. 40:13 (1985).
K.S. Kleinman, and D.C. Zoschke, Suppression of human lymphocyte responses in chronic renal failure mediated by adherent cells: Analysis in serum-free media. J Lab Clin Med. 106:262 (1985).
T. Kunori, I. Feherman, O. Ringden, and E. Möller, In vitro characterization of immunological responseiveness, Nephron. 26:234 (1980).
J.E. Lortan, P. Kiepiela, H.M. Coovadia, and Y.K. Seedat, Suppressor cell assayed by numerical and functional tests in chronic renal failure, Kidney mt. 22:192 (1982).
Y.G. Alevy, K.R. Mueller, and R.G. Slavin, Immune response in experimentally induced uremia. VI. Uremic macrophages are defective in their ability to present antigen to T cells. Clin Immunol and Immunopath. 29:433 (1983).
B. Charpentier, P.H. Lang, B. Martin, J. Noury, D. Marthieu, and D. Fries, Depressed polymorphnuclear leucocyte functions associated with normal cytotoxic functions of T and nature Killer cells during chronic hemodialysis, Clin Nephrology. 19:288 (1983).
J. Nelson, D.J. Ormrod, and T.E. Miller, Host immune status in uremia. IV. Phagocytosis and inflammatory response in vivo. Kidney Int. 23:312 (1983).
K. Osaki, H. Otsuka, K. Uomizu, R. Harada, Y. Otsuji, and S. Hashimoto, Monocyte-mediated mitogen responses of lymphocytes in uremic patients. Nephron. 34:87 (1983).
J. Rubin, L.M. Lin, R. Lewis, J. Cruse, and J.D. Bower, Host defence mechanisms in contnuous ambulatory peritoneal dialysis. Clin Nephrology. 20:140 (1983).
M.D. Smith, G. Hardy, J.D. Williams, G.A. Coles, Suppressor cell numbers and activity in non-transfused renal dialysis patients. Clin Nephrology. 20:130 (1983).
Y.G. Alevy, R. Mueller, J.R. Anderson, P.S. Hutcheson, and R.G. Slavin, The role of monocytes and responder cells in suppression of antigen-specific T cell proliferation in chronic renal failure. Int Archs Allergy Appl Immun. 73:97 (1984).
I. Jatoi, R.G. Slavin, and Y.G. Alevy, Immune response in experimental uremia. VII Uremic thymocytes amplify the response of control lymph node cells to alloantigens. Clin Immunol and Immunopath. 30:80 (1984).
S. Mezzano, A.J. Pesce, V.E. Pollak, and J.G. Michael. Analysis of humoral and cellular factors that contribute to impaired immune responsiveness in experimental uremia. Nephron. 36:15 (1984).
J. Raskova, J. Ghobrial, S. Shea, R. Eisinger, and K. Raska jr.. Suppressor cells in end-stage renal disease. Functional assays and monoclonal antibody analysis. Am J Med. 76:847 (1984).
W.C. Waltzer, R.J. Bachvaroff, A.P. Raisbeck, B. Egelandsdal, C. Pullis, L. Shen, and F.T. Rapaport, Immunological monitoring in patients with end-stage renal disease. J Clin Immunol. 4:364 (1984).
E. Langhoff, and J. Ladefoged, In vitro natural killer and killer cell functions in uremia. Int Archs Allergy Appl Immun. 78:218 (1985).
E. Mirapeix, J. Montolin, C. Suarez, J. Lopez Pedret, and L. Revert, Defective radioresistant suppressor cell activity in hemodialysis patients. Nephron. 41:184 (1985).
D. Donati, P. Cervini, O. Amatruda, L. Baratelli, D. Cassani, A. De Maio, G. Frattini, M. Martegani, and L. Gastaldi, Nutritional state and immune function in uremic patients on maintenance hemodialysis. Proc Int Symp on Immune and Metabolic Aspects of Therapeutic Blood Purification Systems, Trondheim 1985, ed. Smeby LL, Jørstad S, Widerøe T-E, Karger Basel, pp 303–309. (1986).
R.F. Gagnon, Delayed-type hypersensitivity skin reaction in the chronically uremic mouse: Influence of severity and duration of uremia on the development of response. Nephron. 43:16 U986).
P. Kurz, H. Köhler, S. Meuer, T. Hütteroth, and K-H Meyerzum Büschenfelde, Impaired cellular immune responses in chronic renal failure: Evidence of T cell defect, Kidney Int. 29:1209 (1986).
W.D. Tsakolos, Th.C. Theoharides, E.D. Kendler, J. Goffinet, J.M. Dwyer, R.L. Whisler, and P.W. Askenase, Immune defects in chronic renal impairment: evidence for defective regulation of lymphocyte response by macrophages from patients with chronic renal impairment on hemodialysis, Clin Exp Immunol. 63:218 (1986).
I. Fehrman, O. Ringden, and J. Bergström, MLC-blocking factors in uremic sera, Clin Nephrol. 14:183 (1980).
J. Raskova, and K. Raska, Humoral inhibitors of the immune response in uremia. IV. Effects of serum and of isolated serum very low density lipoprotein from uremic rats on cellular immune reactions in vitro. Lab Invest. 45:410 (1981).
G. Delaporte, F. Gros, C. Jonsson, and J. Bergström, In vitro cytotoxic properties of plasma samples from uremic patients, Clin Nephrol. 17:247 (1982).
K. Kamata, M. Okubo, and M. Sada, Immuno-suppressive factors in uremic sera are composed of both dialyzable and non-dialyzable components, Clin Exp Immunol. 54:277 (1983)
P.K. Donnelly, B.K. Shenton, A.M. Alomran, D.M.A. Francis, G. Proud, and R.M.R. Taylor, N new mechanism of humoral immunosuppression in chronic renal failure and its importance to dialysis and transplantation, Proc Europ Dial Transpl Assoc. 20:297 (1983).
M. Rola-Pleszczynski, D. Bolduc, S. Forand, G.E. Plante, and S. St-Pierre, Cellular immune function in uremia: Altered cytotoxic and suppressor cell responses to an immunomodulating heptapeptide, Clin Immunol and Immuno- path. 28:177 (1984).
P. Youing, J. Cledes, J.P. Herve, P. Miossec, and W.J.W. Morrow, Low-affinity E-rosette-blocking factor in hemo- dialysis-treated patients in chronic renal failure, Clin Immunol and Immunopath. 26:423 (1983).
J.F. Mangan, C. Chikkappa, L. Bieler, W.B. Scharfman, and D.R. Parkinson, Regulation of human blood erythroid Burst-Forming-Unit (BFU-E) proliferation by FC receptors and monoclonal antibodies. Blood. 59:990 (1982).
S. Lampari, and S. Carozzi, T lymphocytes, monocytes and erythropoiesis disorders in chronic renal failure. Nephron. 39:211 (1985).
K.G. Chandy, M. Pähl, N.D. Vaziri, and S. Gupa, Acute effects of dialysis on T lymphocytes in patients with end-stage renal disease, J Clin Lab Immunol. 17:119 (1985).
A.M. Badger, D.B. Bernard, B.A. Idelson, and S.R. Cooperband, Depressed spontaneous cellular cytotoxicity associated with normal or enhanced antibody-dependent cellular cytotoxicity in patients with chronic hemodialysis, Clin Exp Immunol. 45:563 (1981).
P. Jüngers, J.F. DeLagneaw, P. Prunet, and J. Crosnier, Vaccination against hepatitis B in hemodialysis centers, Adv Nephrol. 11:303 (1982).
H. Köhler, W. Arnold, G. Renschin, H.H. Dormeyer, and K.H. Meyerzum Buschenfelde, Active hepatitis B vaccination of dialysis patients and medical staff. Kidney Int. 25:124 (1984).
F.G. Casio, G.S. Giebink, C. Le Than, and G. Schiffman, Pneumococcal vaccination in patients with chronic renal disease and renal allograft recipiens. Kidney Int. 20: 254 (1981).
R. Cappel, D. Beers, C. Liesnard, and M. Sratwa, Impaired humoral and cell-mediated immune responses in dialyzed patients after influenza vaccination, Nephron. 33:21 (1983).
J. Nikoskelainen, M. Koskela, J. Forsström, A. Kasanen, and M. Leinonen, Persistence of antibodies to pneumococcal vaccine in patients with chronic renal failure. Kidney Int. 28;672 (1985).
D. Urbanitz, and H.G. Sieberth, Impaired phagocytic activity of human monocytes in respect to reduced antibacterial resistance in uremia, Clin Nephrol. 4:13 (1975).
G. Lahnborg, L. Berghem, T. Ahlgren, L-G Groth, G. Lundgren, and A. Tillegard, Reticuloendothelial function in human renal allograft recipients. Transplantation. 28: 111 (1979).
T.M. Saba, Physiology and physiopathology of the reticuliendothelial system. Arch Intern Med. 126:1031 (1970).
K.L. Rosenstreich, J.J. Farrar, and S. Dougherty, Absolute macrophage dependency of T lymphocyte activation by mitogens. J Immunol. 116:131 (1976).
J. Knop, Influence of various macrophage population on Con A induced T cell proliferation. Immunology 41:379 (1980).
S.A. Rosenberg, and P.E. Lipsky, The role of monocyte factors in the differentiation of Immunglobulin secreting cells from human peripheral blood B cells. J Immunol. 125:232 (1980).
F.G. Meyling, and T.A. Waldmann, Human B cell activation in vitro: augmentation and suppression by monocytes of the Immunglobulin production induced by various B cell stimulants. J Immunol. 126:529 (1981).
D. Metcalf, C.G. Begley, G.R. Johnson, N.A. Nicola, M.A. Vadas, A.F. Lopez, D.J. Williamson, G.G. Wong, S.C. Clark, and E.A. Wang, Biologic properties in vitro of a recombinant human granulocyte-macrophage colony- stimulating factor. Blood 67:37 (1986).
O. Bakke, T. Balstad, L.C. Smeby, S. Jørstad, and T-E. Widerøe, Mononuclear cells (monocytes (OK 141+), T. and Tg+ cells) during hemodialysis. Proc Int Symp on litoune and Metabolic Aspects of Therapeutic Blood Purification Systems, Trondheim 1985, ed. Smeby L.C, Jøirstad S, Widerøe T-E, Karger Basel, pp 105–111 (1986).
R. Korz, U. Loe Guitz, B. Brunner, and R. Heinz, Lymphocyte enzymes of DNA synthesis in chronic renal failure. Proc Eur Dial Transpl Assoc. 13:528 (1976).
R.A. Gutman, and A.T. Auang, Inhibitor, of marrow thymidine incorporation from sera of patients with uremia. Kidney Int. 18:715 (1980).
E.N. Wardle, A study of the possible toxic metabolites of uremia in red cell metabolism. Acta Haematol. 43:129 (1970).
M. Kurada, T. Asaka, Y.M. Tofuku, and R. Takeda, Serum antioxidant activity in uremic patients. Nephron. 41: 293 (1985).
M. Taccone-Galluci, O. Giardini, R. Lubrano, U. Mazzarella, D. Bardino, S. Khashan, O. Mannarino, M. Elli, M. Cozzari, U. Bounteristiani, and C.U. Casciani, Red blood cell membrane lipid peroxidation in continuous ambulatory peritonal dialysis patients. Am J Nephrol. 6:92 (1986).
S. Jørstad and K. E. Viken, Inhibitory effects of plasma from uraemic patients on human mononuclear phagocytes cultured in vitro. Acta Path Microbiol Scand Sect C 859:169 (1977).
S. Jørstad, and S. Kvaernes, Uraemic toxins of high molecular weight inhibiting human mononuclear phagocytes cultured in vitro. Acta Path Microbiol Scand Sect C 86: 221 (1978).
S. Jørstad, L.C. Smeby, T-E. Widerøe, and K.J. Berg, Transport of uremic toxius through conventional hemodialysis membranes. Clin Nephrol. 12:168 (1979).
L.K. Curtiss, and T.S. Edgington, Differential sensitivity of lymphocyte subpopulation to suppression by low density lipoprotein inhibitor, an immunoregulatory human serum low density lipoprotein. J Clin Invest. 63:193 (1979).
D. Modai, J. Weissgarten, U. Shaked, S. Segal, A. Pik, and R. Fuchs, Levamisole circumvents inhibition of lymphocyte activation imposed by uremic serum. Nephron. 40:436 (1985).
P.A. Peterson, P.E. Ervin, and J. Berggard, Differentiation of glomerular, tubular, and normal proteinuria: determinations of urinary excretion of ß2-microglobulin, albumin and total protein, J Clin Invest. 48:1189 (1969).
R.E. Birch, M.W. Fanger, and G.M. Bernier, ß2-microglobulin enhances lymphocyte surface receptor expression for IgG. J Immunol. 122:997 (1979).
P.A. Keown, and B. Descamps, Improved renal graft survival after blood transfusion: a nonspesific erythrocyte mediated immunoregulatory process. Lancet 1:20 (1979).
B.S. Bender, J.L. Curtis, J.E. Nagel, F.J. Chrest, E.S. Kraus, G.R. Briefel, and W.H. Adler, Analysis of immune status of hemodialyzed adults: association with prior transfusions. Kidney Int. 26:436 (1984).
R.M. Hakim, D.T. Fearon, M. Lazarus, and C.S. Perzanowski, Biocompatibility of dialysis membranes: effects of chronic complement activation. Kidney Int. 26:194 (1984).
A.K. Cheung, D.E. Chenoweth, D. Otsuka, and L.W. Henderson, Compartmental distribution of complement activation products in artificial kidneys. Kidney Int. 30:74 (1986).
L. C. Smeby, S. Jørstad, T. Balstad, and T-E. Widerøe, Dialyzer generation and plasma clearance of activated complement during hemodialysis. Proc Int Symp on Immune and Metabolic Aspects of Therapeutic Blood Purification Systems. Trondheim 1985, ed. Smeby LC, Jørstad S, Widerøe T.E, Karger Basel, pp 303 (1986).
D.E. Chenoweth, and T.E. Hugli, Demonstration of specific Cc- receptor on intact human polymorphonuclear leucocytes. Proc Nath Acad Sci USA 75 (8), 3943 (1978).
S.L. Lewis, D.E. Van Epps, and D.E. Chenoweth, C5a- receptor modulation on neutrophils and monocytes from chronic hemodialysis and peritoneal dialysis patients. Clin Nephrol. 26:37 (1986).
R.M. Hakim, J. Breillatt, J.M. Lazarus, and F.K. Port, Complement activation and hypersensitivity reactions to dialysis membranes. Engl j Med. 311:878 (1984).
S. Stefoni, A.N. Costa, M.P. Scolar, L. Coli, G. Mosconi, A. Buscaroli, P. Boni, S. lannelli, T. D. Atena, G. Cianciolo, L. Bruni, and U. Bonomini, DNA-content and surface antigen characteristics of T-cell subsets in chronic dialysis patients. Proc Int Symp on Immune and Metabolic Aspects of Therapeutic Blood Purifcation Systems, Trondheim 1985, ed. Smeby LC, Jørstad S, Widerøe T-E, Karger Basel pp 168 (1986).
Y. Chida, S. Sakurai, and N. Yoshiyama, The effect of hemo dialysis on lymphocyte subsets during dialysis. Clin Nephrol. 25:159 (1986).
M. Bingel, G. Lonnemann, S. Shaldon, K.M. Koch, and C.A. Dinarello, Human interleucin-1 production during hemodialysis. Nephron. 43:161 (1986).
J.E. Hefti, A. Blumberg, and H.R. Marti, Red cell survival and red cell enzymes in patients on continuous peritoneal dialysis (CAPD). Clin Nephrol. 19:232 (1983).
R. Lerner, B. Werner, H. Asaba, B. Ternstedt, and E. Elmqvist, Assessment of hemodialysis in regular hemodialysis patients by measuring carbon monoxide production rate. Clin Nephrol. 20:239 (1983).
C.R. Angle, M.S. Swanson, S.J. Stohs, and R.S. Markin, Abnormal erythrocyte pyrimidin nucleotides in uremic subjects. Nephron. 39:169 (1985).
G. Goubeaud, H.W. Leber, H.H. Schott, and G. Schütterle, Middle molecules and haemoglobulin synthesis. Proc Europ Dial Transpl Assoc. 13:371 (1976).
R.A. Gutman, A.T. Huang, and N.S. Bouknight, Inhibitor of marrow thymidin incorporation from sera of patients with uremia. Kidney Int. 18:715 (1980).
H.W. Radtke, A.B. Rege, M.B. LaMarche, and D. Bartos. Identification of spermine as an inhibitor of Erythro- poiesis in patients with chronic renal failure. Clin Invest. 67:1623 (1981).
R.J.S. McGonigle, J.D. Wallin, R.K. Shadduck, and J.W. Fischer, Erythropoietin deficiency and inhibition of erythropoiesis in renal insufficiency. Kidney Int. 25:437 (1984).
T.E. Widerøe, T. Sanengen, and S. Halvorsen, Erythropoietin and uremic toxicity during continuous ambulatory dialysis. Kidney Int. 24, Suppl 16, 208 (1983).
F. Delwiche, G.M. Segal, J.W. Eschbach, and J.W. Adamson, Hematopoietic inhibitors in chronic renal failure: lack of in vitro specificity. Kidney Int. 29:641 (1986).
J.W. Fisher, Mechanism of the anemia of chronic renal failure. Nephron. 25:106 (1980).
W. Fried, and A. Anagnoston, Extrarenal erythropoietin production. In: Kidney Hormones, ed. Fischer J.W. vol. II:pp 231 (Academic Press, London 1977).
J. Caro, and A.J. Erslev, Uremic inhibitors of erythropoiesis. Semin Nephrol. 5:128 (1985).
B.P. Spragg, D.P. Bentley, and G.A. Coles, Anaemia of chronic renal failure. Polyamines are not raised in uremic serum. Nephron. 38:65 (1984).
D. Meytes, E. Bogin, A. Ma, P.P. Dukes, and S.G. Massry, Effect of parathyroid hormone on erythropoiesis. J Clin Invest. 67:1263 (1981).
F. Delwiche, M.J. Garrity, J.S. Powell, R.P. Robertson, and J.W. Adamson, High level of the circulating form of parathyreoid hormone do not inhibit in vitro erythropoiesis. J Lab Clin Med. 102:613 (1983).
J.B. Sherwood, and E. Goldwasser, A radioimmunoassay for erythropoietin. Blood 54:885 (1979).
P.M. Cotes, Immunoreactive erythropoietin in serum. I. Evidence of the validity of the assay method and the physiological relevance of estimates. Br J Hemat. 50:427 (1983).
M.C. Bordas, N.S. Serbource-Goguel, J.M. Feger, J.M. Maccario, J.M. Agneray, and G.M. Durand, Evaluation of the degree of desialynation of serum a--acid glucoprotein and a.-antitrypsin. Clin Chim Acta. 125:311 (1982).
H. Lewinsky, U. Gafter, J. Levi, and D. Allalouf, Neuramidase-like activity in sera of uremic anemic patients, Nephron. 37:35 (1984).
J.S. Shannon, T.R.J. Lappin, G.E. Elder, G.M. Roberts, M.G. McGeown, and J.M. Bridges, Increased plasma glycosidase and protease activity in uraemia: possible role in the aetiology of the anaemia of chronic renal failure. Clin Chim Acta. 153:203 (1985).
J.I. Kurland, A. Meyors, and M.A.S. Moore, Synthesis and release of erythroid colony-and burst-potentiating activities by purified populations of murine peritoneal macrophages. J Exp Med. 151:839 (1980).
J.N. Rich, W. Heit, and B. Kubanek, An erythropoietic stimulating factor similar to erythropoietin released by macrophages after treatment with silica. Blut 4: 297 (1980).
K. Jacobs, C. Shoemaker, R. Rudersdorf, S.D. Neill, R.J. Kaufman, A. Mufson, J. Seehra, S.S. Jones, R. Hewich, E.F. Fritsch, M. Kawakita, T. Shimizu, and T. Miyake, Isolation and characterization of genomic and cDNA clones of human erythropoietin. Nature 313:806 (1985).
J.W. Eschbach, J. Mladenovic, J. F. Garcia, P. W. Wahl, and J. W. Adamson, The anemia of chronic renal failure sheep. Response to erythropoietin-rich plasma in vivo. J Clin Invest. 74:434 (1984).
J. Mladenovic, J.W. Eschbach, J.R. Koup, J.F. Garcia, and J.W. Adamson, Erythropoietin kinetics in normal and uremic sheep. J Lab Clin Med. 195:659 (1985).
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Widerøe, TE. (1987). Uremic Dysmetabolism and Its Effect on Immunocompetent and Erythroid Cell Function. In: Ringoir, S., Vanholder, R., Massry, S.G. (eds) Uremic Toxins. Advances in Experimental Medicine and Biology, vol 223. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5445-1_28
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