Abstract
Some organic acids which inhibit binding of small ligands to plasma, so called protein binding inhibitors (PB-Ix), accumulate in body fluids of patients with renal failure. PB-Ix are believed to bind to sites on the surface of albumin and inhibit its detoxification, transport and reservoir functions1)2)3). They may play a wider toxic role, such as immunosuppression in uremic patients. PB-Ix have been shown to inhibit the mitogenic activity of lymphocytes4).
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References
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© 1987 Plenum Press, New York
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Sanaka, T. et al. (1987). Binding of Organic Acids to Surface Receptors of Lymphocytes as an Immunosuppressive Mechanism in Uremia. In: Ringoir, S., Vanholder, R., Massry, S.G. (eds) Uremic Toxins. Advances in Experimental Medicine and Biology, vol 223. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5445-1_27
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DOI: https://doi.org/10.1007/978-1-4684-5445-1_27
Publisher Name: Springer, Boston, MA
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