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Isolation of an Immunosuppressive Fraction from Uremic Ultrafiltrates

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Uremic Toxins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 223))

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Abstract

Cell mediated immune responses were decreased in patients with chronic renal failure (CRF) and this deficiency was shown to be mainly dependent on toxic or inhibitory serum factors. In previous study we have reported the isolation of a crude fraction from uremic sera with immunosuppressive properties 1,2. This crude fraction which has a molecular weight (MW) below 5.000 daltons, inhibits markedly the lymphocyte proliferation induced by several mitogens or by allogeneic cells1. Further attempts to purify and characterize this immunosuppressive factor are presented. The inhibitory effect of each eluate fraction on in vitro lymphocyte proliferation has been assessed at each step of purification.

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References

  1. J. Navarro, J.L. Touraine, C. Corre, J. Traeger, Effet in vitro des “moyennes molecules” sur la prolifération lymphocytaire. Path. Biol. 24: 189 (1976)

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  2. J. Navarro, J.L. Touraine, C. Corre, J. Traeger, Prolongation of skin allograft survival and inhibition of graft versus host reaction in rodents treated with “middle molecules”. Cell. Immunol. 31: 349 (1977)

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  3. J. Navarro, M.C. Grossetête, A. Defrasne, J.L. Touraine, J. Traeger, Isolation of an immunosuppressive fraction in ultrafiltrate from uremic sera. Nephron 40: 396 (1985)

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Author information

Authors and Affiliations

  1. Inserm U.80, CNRS UA 1177, UCB, Lyon, France

    J. Navarro, M. C. Grossetête, J. L. Touraine & J. Traeger

Authors
  1. J. Navarro
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  2. M. C. Grossetête
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  3. J. L. Touraine
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  4. J. Traeger
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Editor information

Editors and Affiliations

  1. University of Ghent, Ghent, Belgium

    Severin Ringoir  & Raymond Vanholder  & 

  2. University of Southern California, Los Angeles, California, USA

    Shaul G. Massry

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© 1987 Plenum Press, New York

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Navarro, J., Grossetête, M.C., Touraine, J.L., Traeger, J. (1987). Isolation of an Immunosuppressive Fraction from Uremic Ultrafiltrates. In: Ringoir, S., Vanholder, R., Massry, S.G. (eds) Uremic Toxins. Advances in Experimental Medicine and Biology, vol 223. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5445-1_26

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  • DOI: https://doi.org/10.1007/978-1-4684-5445-1_26

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5447-5

  • Online ISBN: 978-1-4684-5445-1

  • eBook Packages: Springer Book Archive

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