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Uremic Toxins Inhibit the Platelet Malonyldialdehyde Production Rate

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Book cover Uremic Toxins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 223))

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Abstract

Platelet cyclo-oxygenase activity is known to be low in uremic patients1,2, but it is still lower in maintenance hemodialysis patients3. Malonyldialdehyde (MDA) is one of the terminal substances from arachidonic acid, which is converted to prostaglandins by cyclo-oxygenase. Although some MDA are produced through other pathways, the platelet MDA production rate is used to evaluate platelet cyclo-oxygenase activity and is a guideline in detecting the abnormality of prostaglandin metabolism. The aim of this study is to find out the inhibiting factor of this platelet MDA production rate in hemodialysis patients. We observed the level of inhibition of the activity of normal platelets incubated with several kinds of substances which are suspected to be uremic toxins.

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References

  1. G. Remuzzi, A. Benigni, P. Dodesini, A. Schieppati, M. Livio, G. De Gaetano, J. S. Day, W. L. Smith, E. Pinea, P. Patrignani, and C. Patrono, Reduced platelet thromboxane formation in uremia, J. Clin. Invest. 71:762 (1983).

    Article  PubMed  CAS  Google Scholar 

  2. O. Ylikorkala, K. Huttunen, J. Jarvi, and L. Viinikka, Prostacyclin and thromboxane in chronic uremia: effect of hemodialysis, Clin. Nephrol. 18:83 (1981).

    Google Scholar 

  3. H. Tanaka, K. Umimoto, N. Izumi, K. Nishimoto, T. Maekawa, T. Kishimoto, and M. Maekawa, Platelet life span in uraemia, Proc. Euro. Dial. Transpl. Assoc. 21:306 (1984).

    Google Scholar 

  4. M. Okuma, M. Steiner, and M. Baldini, Studies on lipid peroxides in platelets, J. Lab. Clin. Med. 75:283 (1970).

    PubMed  CAS  Google Scholar 

  5. H. Tanaka, K. Umimoto, N. Izumi, K. Nishimoto, H. Yoshihara, Y. Katoh, T. Kishimoto, and M. Maekawa, Platelet dysfunction and its life span in uremia. Trans. Am. Soc. Artif. Intern. Organs 30:207 (1984).

    PubMed  CAS  Google Scholar 

  6. G. Remuzzi, D. Marchesi, M. Livio, A. Schieppati, G. Mecca, M. B. Donati, and G. De Gaetano, Prostaglandins, plasma factors, and hemostasis in uremia, in: "Hemostasis, Prostaglandins, and Renal Disease," G. Remuzzi, G. Mecca, G. De Gaetano, eds., Raven Press, New York (1980).

    Google Scholar 

  7. M. C. Smith and M. J. Dunn, Impaired platelet thromboxane production in renal failure. Nephron 29:133 (1981).

    Article  PubMed  CAS  Google Scholar 

  8. S. Karpatkin, Heterogeneity of human platelets. VI. Correlation of platelet function with platelet volume, Blood 51:307 (1978).

    PubMed  CAS  Google Scholar 

  9. M. Kraytman, Platelet size in thrombocytopenias and thrombocytosis of various origin. Blood 41:587 (1973).

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Urology, Osaka City University Medical School, 1-5-7 Asahimachi, Abenoku, Osaka 545, Japan

    H. Tanaka, S. Itoh, S. Yamagami, T. Kishimoto & M. Maekawa

  2. Renal Division, University Hospital, De Pintelaan 185, B-9000, Ghent, Belgium

    S. Ringoir

Authors
  1. H. Tanaka
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  2. S. Itoh
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  3. S. Yamagami
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  4. T. Kishimoto
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  5. M. Maekawa
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  6. S. Ringoir
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Editor information

Editors and Affiliations

  1. University of Ghent, Ghent, Belgium

    Severin Ringoir  & Raymond Vanholder  & 

  2. University of Southern California, Los Angeles, California, USA

    Shaul G. Massry

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© 1987 Plenum Press, New York

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Tanaka, H., Itoh, S., Yamagami, S., Kishimoto, T., Maekawa, M., Ringoir, S. (1987). Uremic Toxins Inhibit the Platelet Malonyldialdehyde Production Rate. In: Ringoir, S., Vanholder, R., Massry, S.G. (eds) Uremic Toxins. Advances in Experimental Medicine and Biology, vol 223. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5445-1_16

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  • DOI: https://doi.org/10.1007/978-1-4684-5445-1_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5447-5

  • Online ISBN: 978-1-4684-5445-1

  • eBook Packages: Springer Book Archive

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