Abstract
Many investigators have described the large number of unknown solutes of low molecular weight, within the purine range, which accumulate in the plasma during progressive reduction in renal function (1). Their identification is important both in terms of understanding the toxicity which occurs in uraemia and in devising new therapeutic approaches, particularly for dialysis. The question is whether some of these could be purines and if so what would the significance of this be? Elevated plasma cAMP levels which correlated with plasma creatinine concentrations were the first purines to be implicated in renal failure (1). Since all cells require a balanced supply of purines for growth and survival it is clear that there may be other abnormalities.
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References
Bergstrom J, Fürst P. Uraemic Toxins. Chapter 19. In: Drukker W, Parsons FM, Maher JF, eds. Replacement of renal function by dialysis. Boston: Martinus Nijhoff, 1983; 2nd Edition: 354–390.
Henderson JF, Paterson ARP. Nucleotide Metabolism: an introduction. NY: Academic Press 1973.
Simmonds HA, Van Acker KJ. Adenine phosphoribosyltransferase deficiency: 2,8-dihydroxyadenine lithiasis. Chapter 52. In: Stanbury JB, Wyngaarden JB, Fredricksen DA, Goldstein JL, Brown MS, eds. The metabolic basis of inherited disease. NY: McGraw-Hill, 1983; 5th edition: 1144–1156.
Hershfield MS. S-adenosylhomocysteine hydrolase as a target in genetic and drug-induced deficiency of adenosine deaminase. In: Berne RM, Rail TW, Rubio R, eds. Regulatory function of adenosine. The Hague: Martinus Nijhoff, 1983: 171–177.
Various authors. Ibid.
Niklasson F. Experimental and clinical studies on human purine metabolism. Abstracts of Uppsala Dissertations from the Faculty of Medicine. Uppsala: Fyrus Tryk, 1983.
Thompson CI, Sparks HV, Spielman WS. Renal handling and production of plasma and urinary adenosine. Am J physiol 1985; 248:F545-F551.
Cameron JS, Simmonds HA. Uric acid, gout and the kidney. J Clin Pathol 1981; 34:1245–1254.
Cohen BD. Uraemia: pillar of salt or column of nitrogen? Editorial. Dialysis & Transplantation 1980; 9:535–538.
Mikami H, Orita Y, Ando A, Fujii M, Kikuchi T, Yoshihara K, Okada A, Abe H. Metabolic pathway of guanidino compounds in chronic renal failure. In: Lowenthal A, Mori A, Marescau B, eds. Urea cycle disorders. NY:Plenum Press 1983:449–458.
Jones JD, Burnett PC. Creatinine metabolism in humans with decreased renal function:creatinine deficit. Clin Chem 1974; 20:1204–1212.
Simmonds HA, Cameron JS, Morris GS, Davies PM. Allopurinol in renal failure and the tumour lysis syndrome. Clin Chim Acta 1986; in press.
Greenwood MC, Dillon MJ, Simmonds HA, Barratt TM, Pincott JR, Metreweli C. Renal failure due to 2,8-dihydroxyadenine urolithiasis. Eur J Paediatr 1982;138:346–349.
Kishi T, Kittaka E, Hyodo S, Kashiwa H, Karakawa T, Suzawa T, Sakura N, Sakano T, Usui T. Inhibition by adenine of in vitro immunological functions of normal and adenine phosphoribosyltransferase deficient human lymphocytes. Immunopathol. 1985;10:157–162.
Simmonds HA, Watson AR, WEbster DR, Sahota A, Perrett D. GTP depletion and other erythrocyte abnormalities in inherited PNP deficiency. Biochem Pharmacol 1982; 31:941–946.
Morris GS, Simmonds HA. A single system for the evaluation of purine and pyrimidine nucleosides and bases together with their analogues in biological fluids. Adv Exp Med Biol 1986; 195A:593–601.
Schoots AdC, Homan HR, Gladdines MM, Cramers CAMG, de Smet R, Ringoir SMG. Screening of UV-absorbing solutes in uremic serxim by reversed phase HPLC — change of blood levels in different therapies. Clin Chim Acta 1985; 146:37–51.
Becher HJ, Weise HJ, Volkermann U, Schollmeyer P. Enhanced purine nucleotide synthesis in erythrocytes of uraemic patients. Klin Wochenschr 1980; 58:1243–1250.
Rejman ASM, Mansell MA, Grimes AJ, Joekes AM. Rapid correction of red cell nucleotide abnormalities following successful renal transplantation. Br. J Haematol 1985; 61:433–443.
Angle CR, Swanson MS, Stohs SJ, Markin RS. Abnormal erythrocyte pyrimidine nucleotides in uraemic subjects. Nephron 1985; 39:169–174.
Sabina RL, Holmes EW, Becker MA, The enzymatic synthesis of 5-amino-4-imidazolecarboxamide riboside triphosphate (ZTP). Science 1984;223:1193–1195.
Gazitt Y, Ohad I, Loyter A. Changes in phospolipid susceptibility toward phosphlipases induced by ATP depletion in avian and amphibian erythrocyte membranes. Biochim Biophys Acta 1975; 382:65–72.
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© 1987 Plenum Press, New York
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Simmonds, H.A., Cameron, J.S., Morris, G.S., Fairbanks, L.D., Davies, P.M. (1987). Purine Metabolites in Uraemia. In: Ringoir, S., Vanholder, R., Massry, S.G. (eds) Uremic Toxins. Advances in Experimental Medicine and Biology, vol 223. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5445-1_10
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DOI: https://doi.org/10.1007/978-1-4684-5445-1_10
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