Abstract
On first sight a paper on mast cell signalling processes would seem to be out of place amongst contributions which are mainly concerned with T cell receptor-ligand interactions. As I hope will become apparent, however, our observations on the manner in which IgE antibodies initiate the release of mediators of immediate-type allergy from mast cells could be more than a little relevant to a better understanding of T cell recognition and trigger processes.
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References
Bennich, H, and Hahr-Lindstrom, H Von (1978). Structure of immunoglobulin E. Prog. Immun. II, 1, 49–58.
Burt, D S, Hastings, G Z, and Stanworth, D R (1986). Localisation of binding site(s) on IgE for a specific receptor on mast cells. Protides of the Biol. Fluids 34th Colloq. 243–246. Ed. H Peeters (Pergamon Press).
Coleman, J W, Helm, B, Stanworth, D R, and Gould, H (1985). “Inhibition of IgE effector function by a dimeric human c-chain fragment in E. colf.
Deisenhofer, J (1981). Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9–2.8A resolution. Biochemistry 20, 2361–2370.
Dennis, S et al (1986). Hepp (IgE pentapeptide) in allergic rhinítis. J. Allergy Clin. Immunol. 77, 213 (Abstr.).
Dorrington, K J, and Bennich, H (1978). Structure-function relationships in human immunoglobulin E. Immun. Rev. 41, 13–25.
Dufton, M J, Cherry, R J, Coleman, J W, and Stanworth, D R (1984). The capacity of basic peptides to trigger exocytosis from mast cells correlates with their capacity to immobilize band 3 proteins in erythrocyte membranes. Biochem. J. 223, 67–71.
Hamburger, R N (1975). Peptide inhibition of Prausnitz-Küstner reaction. Science 189, 389–390.
Hellman, L, Petterson, U, Ensstrom, A, Karsson, I, and Bennich, H (1982). Structure and evolution of the heavy chain from rat immunoglobulin E. Nucl. Acid. Res. 10, 6041–6049.
Holowka, D, and Baird, B (1983). Structural studies on the membrane-bound immunoglobulin E-receptor complex. 2. Mapping of distances between sites on IgE and the membrane surface. Biochemistry 22, 3475–3484.
Ishizaka, T, and Ishizaka, K (1978). Triggering of histamine release from rat mast cells by divalent antibodies against IgE receptors. J. Immunol. 120, 800–805.
Jasani, B, Kreil, G, Mackler, B F, and Stanworth, D R (1973). Studies on mast cell triggering action of certain artificial histamine liberators. Int. Archs. Allergy Appl. Immun. 45, 74–81.
Jasani, B, Krell, G, Mackler, B F, and Stanworth, D R (1979). Further studies on the structural requirements for polypeptide - mediated histamine release from rat mast cells. Biochem. J. 181, 623–632.
Merrifield, R B (1963). Solid phase peptide synthesis and the syntheis of a tetrapeptide. J. Am. Chem. Soc. 85, 2149–2154.
Perez-Montfort, R, and Metzger, H (1982). Proteolysis of soluble IgEreceptor complexes: localisation of sites on IgE which interact with the Fc receptor. Molec. Immunol. 19, 113–125.
Roy, P D, Moran, D M, Bryant, V, Stevenson, R, and Stanworth, D R (1980). Further studies on histamine release from rat mast cells in vitro induced by peptides. Biochem. J. 191, 233–237.
Stanworth, D R (1971). Immunoglobulin E (reagin) and allergy. Nature Lond. 233, 310–316.
Stanworth, D R (1973). Immediate hypersensitivity: the molecular basis of the allergic response. “Frontiers of Biology” Series ( North Holland, Amsterdam).
Stanworth, D R (1984). The role of non-antigen receptors in mast cell triggering processes. Molec. Immunol. 21, 1183–1190.
Stanworth, D R, and Kuhns, W J (1965). Quantitative studies on the assay of human skin-sensitizing antibodies (reagins). Immunology 8, 323–344.
Stanworth, D R, and Burt, D S (1986). Anti-c-chain antibodies as probes in the studyof mast cell triggering. Molec. Immunol. 23, 1231–1235.
Stanworth, D R, Coleman, J W, and Khan, Z (1984). Essential structural requirements for triggering of mast cells by a synthetic peptide comprising a sequence in the Ce4 domain of human IgE. Molec. Immunol. 21, 243–247.
Stanworth, D R, King, S M, Roy, P D, and Moran, D M (1978). Investigation of the reputed inhibition of the Prausnitz-Küstner reaction by the pentapeptide Asp-Ser-Asp-Pro-Arg. Int. Archs. Allergy Appl. Immun. 56, 409–415.
Stanworth, D R, Burt, D S, and Hastings, G Z (1986). The use of synthetic peptides in the delineation of immunoglobulin antigenic epítopes and Fc effector functions. Ciba Found. Symp. 119, 226–244.
Stanworth, D R, Humphrey, J H, Bennich, H, and Johansson, S G O (1968). Inhibition of Prausnitz-Kästner reaction by proteolytic-cleavage fragments of human myeloma protein of immunoglobulin class E. Lancet ii, 17–18.
Stanworth, D R, King, S M, Roy, P D, Moran, J M, and Moran, D M (1979). Synthetic peptides comprising sequences of the human immunoglobulin E heavy chain capable of releasing histamine. Biochem. J. 180, 665–668.
Sutton, B J, Burt, D S, Hastings, G Z, and Stanworth, D R (1987). Modelling of the mast cell Fc (e) R combining sites of rat IgE. In preparation.
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Stanworth, D.R. (1987). Use of Synthetic Peptides in the Delineation of the Role of Non-Antigen Receptors in Mast Cell Signalling Processes. In: Atassi, M.Z. (eds) Immunobiology of Proteins and Peptides IV. Advances in Experimental Medicine and Biology, vol 225. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5442-0_18
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DOI: https://doi.org/10.1007/978-1-4684-5442-0_18
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