Abstract
The helper T-cell recognition of globular protein antigens appears, in general, to require the intracellular processing of the antigen such that a peptide fragment containing the T-cell’s antigenic determinant is released, is transported to and held on the surface of an Ia expressing cell. However, the molecular details underlying these phenomena are largely unknown.
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References
Finnegan, A., Smith, M. A., Smith, J. A., Berzofsky, J., Sachs, D. H., and Hodes, R. J., 1986, The T cell repertoire for recognition of a phylogenetically distant protein antigen, J. Exp. Med., 164: 897–910.
Hannum, C., Matis, L. A., Schwartz, R. H., and Margoliash, E., 1985, The B10.A mouse B cell response to pigeon cytochrome c is directed against the same area of the protein that is recognized by B10.A T cells in association with the Ek:Eâ la molecule, J. Immunol. 135: 3314–3322.
Lakey, E. K., Margoliash, E., and Pierce, S. K., 1986a, Identification of a peptide binding protein which plays a role in antigen presentation. Proc. Natl. Acad. Sci. USA, in press.
Lakey, E. K., Margoliash, E., Fluoret, G., and Pierce, S. K., 1986b, Peptides related to the antigenic determinant block T cell recognition of the native protein as processed by antigen-presenting cells, Eur. J. Immunol. 16: 721–727.
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© 1987 Plenum Press, New York
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Lakey, E.K., Smith, J.A., Margoliash, E., Pierce, S.K. (1987). A Peptide Binding Protein Which Plays a Role in Antigen Presentation. In: Atassi, M.Z. (eds) Immunobiology of Proteins and Peptides IV. Advances in Experimental Medicine and Biology, vol 225. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5442-0_13
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DOI: https://doi.org/10.1007/978-1-4684-5442-0_13
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