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Different Presynaptic Receptors Modulate Neuronal Uptake and Transmitter Release in Serotoninergic Nerve Terminals

  • Chapter
Receptor-Receptor Interactions

Part of the book series: Wenner-Gren Center International Symposium Series ((WGCISS))

Abstract

The concept of presynaptic receptors modulating the release of neurotransmitters has arisen from studies on peripheral noradrenergic neurons (Langer, 1974, 1981, Starke, 1981), and has now been extended to the central nervous system for several neurotransmitters, such as noradrenaline, serotonin, acetylcholine and dopamine. It is possible to differentiate between presynaptic inhibitory autoreceptors, acted upon by transmitters which can regulate their own release and in some cases their synthesis, and presynaptic heteroreceptors sensitive to endogenous compounds other than the neuron’s own transmitter. Such substances include co-transmitter neuropeptides, transmitters released from adjacent terminals, or locally or blood-borne substances which can facilitate or inhibit the calcium-dependent release of the neurotransmitter.

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Authors
  1. Salomon Z. Langer
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  2. Anne-Marie Galzin
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Editor information

Editors and Affiliations

  1. Department of Histology, Karolinska Institutet, Box 60400, 104 01, Stockholm, Sweden

    Kjell Fuxe

  2. Department of Human Physiology, University of Modena, Via Campi 287, 411 00, Modena, Italy

    Luigi F. Agnati

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© 1987 The Wenner-Gren Center

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Langer, S.Z., Galzin, AM. (1987). Different Presynaptic Receptors Modulate Neuronal Uptake and Transmitter Release in Serotoninergic Nerve Terminals. In: Fuxe, K., Agnati, L.F. (eds) Receptor-Receptor Interactions. Wenner-Gren Center International Symposium Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5415-4_30

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  • DOI: https://doi.org/10.1007/978-1-4684-5415-4_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5417-8

  • Online ISBN: 978-1-4684-5415-4

  • eBook Packages: Springer Book Archive

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