Abstract
Burnstock (1982) has summarized evidence suggesting that adenosine triphosphate (ATP) acts as a co-transmitter or neuromodulator in a variety of tissues. This paper concerns ATP and the neuromuscular junction of skeletal muscle and also the embryonic muscle cell, represented by cultured myotubes.
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Adamo, S., Zani, B. M., Nervi, C., Senni, M. I., Molinaro, M. & Eusebi, F. (1985) Acetylcholine stimulation phosphatidylinositol turnover at nicotinic receptors of cultured myotubes. FEBS Lett., 190, 161–164.
Abood, L.G., Koketsu, K. & Miyamoto S. (1962) Outflux of various phosphates during membrane depolarization of excitable membranes. Am. J. Physiol., 202, 469–474.
Akasu, T., Hirai, K. & Koketsu, K. (1981) Increase in acetylcholine receptor sensitivity by adenosine triphosphate: a novel action of ATP on ACh-sensitivity. Br. J. Pharmac., 74, 505–507.
Berridge, M.J. & Irvine, R.F. (1984) Inositol triphosphate, a novel second messenger in cellular signal transduction. Nature, 312, 315–321.
Buchthal, F. & Folkow, B. (1948) Interaction between acetylcholine and adenosine triphosphate in normal, curarized and denervated muscle. Acta Physiol. Scand., 15, 150–160.
Burnstock, G. & Kennedy, C. (1985) Is there a basis for distingguishing two types of P2-purinoceptor ? Gen. Pharmac., 16, 433–440.
Desmedt, J.E. (1978) Muscular dystrophy contrasted with denervation: different mechanisms underlying spontaneous fibrillations. In Contemporary clinical neurophysiology. eds. WA Cobb & H Van Duijm). Elsevier, ART6751W.
Dowdall, M.J., Boyne, A.F. & Whittaker, V.P. (1974) Adenosine triphosphate, a constituent of cholinergic synaptic vesicles. Biochem. J., 140, 1–12.
Eusebi, F., Molinaro, M. & Zani, B.M. (1985) Agents that activate protein kinase C reduce acetylcholine sensitivity in cultured myotubes. J. Cell. Biol., 100, 339–1343.
Ewald, D.A.J. (1976) Potentiation of postjunctional sensitivity of rat diaphragm by high-energy-phosphate adenine nucleotides. J. Membr. Biol., 29, 47–65.
Gilliat, R.W. & Westgaard, R.H. (1978) Nerve-muscle interactions. In Contemporary clinical neurophysiology. (eds. WA Cobb &; H Van Duijm) Elsevier, Amsterdam.
Ginsborg, B.L. & Hirst, G.D.S. (1972) The effect of adenosine on the release of transmitter from the phrenic nerve of the rat. J. Physiol. (Lond.), 224, 629–645.
Giompres, P.E., Zimmermann, H. & Whittaker, V.P. (1981) Changes in the biochemical and biophysical parameters of cholinergic synaptic vesicles on transmitter release and during subsequent period of rest. Neuroscience, 6, 775–785.
Gordon, A.S., Guillory, R.J., Diamond, I. & Hucho, F. (1979) ATP-binding proteins in acetylcholine receptor enriched membranes. FEBS Lett., 108, 37–39.
Grondai, E.J.M. & Zimmermann, H. (1986) Ectonucleotidase activities associated with cholinergic synaptosomes isolated from Torpedo electric organ. J. Neurochem., 47, 871–881.
Häggblad, J. (1986) Neuromuscular junction revisited: Biochemical studies on mechanisms involved in transmission events. Doctoral dissertation, manuscript. University of Stockholm, Sweden.
Häggblad, J. & Heilbronn, E. (1986) Externally applied ATP causes inositol triphosphate accumulation in cultured chick myotubes. Neurosci Lett., in press.
Häggblad, J., Eriksson, H., Hedlund, B. & Heilbronn, E. (1986) Forskolin blocks agonist mediated permeabilitx of chick myotube nicotinic receptors and inhibits binding of H-phencyclidine to Toredo microsac nicotinic receptors. Naunyn Schm. Arch. Pharmac., submitted.
Häggblad, J., Eriksson, H., & Heilbronn., E. (1985a) ATP induced cation influx in myotubes is additive to cholinergic agonist action. Acta Physiol. Scand., 125, 389–393.
Häggblad, J., Eriks§pn, H., & Heilbronn, E. (1985b) Effects of extracellular ATP on Rb-influx in chick myotubes: Indications of a cotransmitter role in neuromuscular transmission. In Molecular basis of nerve activity. (eds. J-P Changeux, F Hucho, A Maelicke & E Neumann) Walter de Gruyter, Berlin, New York.
Heilbronn, E. & Häggblad, J. (1986) A case for ATP as a neurotransmitter and trigger of postsynaptic Ca-release at the neuromuscular junction? In Cellular and molecular basis of cholinergic funtion. (ed. M J Dowda, in press.Heppl, L.A., Weisman, G.A. & Friedberg, I. (1985) Permeabilization of transformed cells in culture by external ATP. J. Membr. Biol., 86, 189–196.
Herbison, G. J., Jaweed, M.M. & Ditunno, J. F. (1983) Acetylcholine sensitivity and fibrillation potentials in electrically stimulated crush denervated rat sekeltal muscle. Arch. Phys. Med. Rehabil. 64, 217–220.
Huganir, R. L., Delcour, A. H., Greengard, P., and Hess, G. P. (1986) Phosphorylation of the nicotinic acetylcholine receptor regulates its rate of desensitization. Nature, 321, 774–775.
Israel, M., Lesbats, B., Manaranche, R., Meunier, F.M. & Frachon, P. (1980) Retrograde inhibition of transmitter release by ATP. J. Neurochem., 34, 923–932.
Kolb, H.A. & Wakelam, M.J.O. (1983) Transmitter-like effects of ATP on patched membranes of cultured myoblaste and myotubes. Nature, 303, 621–623.
Kuffler, S.W. & Nicholls, J.G. (1976) From neurone to brain. Sinauer Ass. Inc., Sunderland, MA, USA.
LOmo, T. (1976) The role of activity in the control of membrane and contractile properties of skeletal muscle. In Motor innervation of muscle. (ed. S Thesleff). Academic Press, London.
LOmo, T. & Westgaard, R. H. (1975) Further studies on the control of ACh sensitivity by muscle activity in the rat. J. Physiol (Lond.), 252, 603–626.
Meunier, F.M. & Morel, N. (1978) Adenosine uptake by cholinergic synaptosomes from Torpedo electric organ. J. Neurochem., 31, 845–851.
Middleton, P., Jaramillo, F. & Schuetze, S.M. (1986) Forskolin increases the rate of acetylcholine receptor desensitization in rat soleus endplates. Proc. Natl. Acad. Sci. USA, 83, 4967–4971.
Miyamoto, M.D. & Breckenridge, B.McL. (1974) A cyclic adenosine monophosphate link in the catecholamine enhancement of transmitter release at the neuromuscular junction. J. Gen. Physiol., 63, 609–624.
Nemeth, P.M. (1982) Electrical stimulation of denervated muscle prevents decreases in oxidative enzymes. Muscle & Nerve, 5, 134–139.
Nix, W. A. (1982) The effect of low-frequency electrical stimulation on the denervated extensor digitorum longus muscle of the rabbit. Acta Neurol. Scand., 66, 521–528.
Ribeiro, J.A. & Dominguez, M.L. (1978) Mechanisms of depression of neuromuscular transmission by ATP and adenosine. J. Physiol. (Paris), 74, 491–496.
Ribeiro, J.A. & Sebastiao, A.M. (1985) On the type of receptor involved in the inhibitory action of adenosine at the neuromuscular junction. Br. J. Pharmac., 84, 911–918.
Ribeiro, J.A. & Sebastiao, A.M. (1986) Adenosine receptors and calcium: Basis for proposing a third (A3) adenosine receptor. Prog. Neurobiol., 26, 179–209.
Ribeiro, J.A. & Walker, J. (1975) The effects of adenosine triphosphate and adenosine diphosphate on transmission at the rat and frog neuromuscular junctions. Br. J. Pharmac., 54, 213–218.
Rozengurt, E., Heppel, L.A. & Friedberg, I. (1977) Effect of exogenous ATP on the permeability properties of transformed mouse cell lines. J. Biol. Chem., 252, 4584–4590.
Sekar, M.C. & Hokin, L.E. (1986) The role of phosphoinositides in signal transduction. J. Membr. Biol., 89, 193–210.
Silinsky, E.M. (1984) On the mechanism by which adenosine receptor activation inhibits the release of acetylcholine from motor nerve endings. J. Physiol. (Lond.) 346:243–256.
Silinsky, E.M. & Ginsborg, B.L. (1983) Inhibition of acetylcholine release from preganglionic frog nerves by ATP but not by adenosine. Nature, 305, 327–328.
Silinsky, E.M. & Hubbard, J.I. (1973) Release of ATP from rat motor nerve terminals. Nature, 234, 404–405.
Suskiw, J.B. & Pilar, G. (1976) Selective localization of a high affinity choline uptake system and its role in ACh formation in cholinergic nerve terminals. J. Neurochem., 26, 1133–1138.
Tashiro, T. & Stadtler, H. (1978) Chemical compositions of cholinergic synaptic vesicles from Torpedo marmorata based on improved purification. Eur. J. Biochem., 90, 479–487.
Valencic, V., Vodovnok, L., Stefancic, M. & Jelnikas, T. (1986) Improved motor response due to chronic electric stimulation of denervated tibialis anterior muscle in humans. Muscle & Nerve, 9, 612–617.
Vergara, J., Tsien, R.Y. & Delay, M. (1985) Inositol 1,4,5trisphosphate: A possible chemical link in excitation-contraction coupling in muscle. Proc. Natl. Acad. Sci. USA, 82, 6352–6356.
Volknandt, W. & Zimmermann, H. (1986) Acetylcholine, ATP and proteoglycan are common to synaptic vesicles isolated from electric organs of electric eel and electric catfish as well as from rat diaphragm. J. Neurochem., 47, 1449–1462.
Volpe, P., DiVirgilio, F., Pozzan, T. & Salviati, G. (1986) Role of inositol 1,4,5-trisphosphate in excitation-contraction coupling in skeletal muscle. FEBS Lett., 197, 1–4.
Wagner, J.A., Carlson, S.S. & Kelly, R.B. (1978) Chemical and physical characterization of cholinergic synaptic vesicles. Biochemistry, 17, 1199–1206.
Weisman, G.A., De, B.K., Friedberg, I., Pritchard, R.S. & Heppel, L.A. (1984) Cellular responses to external ATP which precede an increase in nucleotide permeability in transformed cells. J. Cell. Physiol., 119, 211–219.
Zimmermann, H. & Bokor, J.T. (1979) ATP recycles independently of ACh in cholinergic synaptic vesicles. Neurosci. Lett., 13, 319–324.
Zimmermann, H. & Whittaker, V.P. (1974) Effect of electrical stimulation on the yield and composition of synaptic vesicles from cholinergic synapses of the electric organ of Torpedo: a combined biochemical, electrophysiological and morphological study. J. Neurochem., 22, 435–450.
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Heilbronn, E., Häggblad, J. (1987). Adenosine Triphosphate: ‘Pre-transmitter’, Co-transmitter or Modulator at the Skeletal Muscle?. In: Fuxe, K., Agnati, L.F. (eds) Receptor-Receptor Interactions. Wenner-Gren Center International Symposium Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5415-4_28
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DOI: https://doi.org/10.1007/978-1-4684-5415-4_28
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