Abstract
There is continuous formation of adenosine in all cells. Methyltransferase reactions lead to the formation of S-adenosylhomocysteine, which is rapidly broken down to form adenosine. The rate of adenosine formation is markedly enhanced by any procedure that leads to a dissociation between the rate of ATP-production and the rate of ATP-utilization. Thus, adenosine levels rapidly increase in tissues whenever there is a threatening depletion of high-energy phosphate compounds from any of the cells in the tissue. Adenosine may be thought of as a signal of the metabolic state of a tissue or a group of cells.
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References
Daly, J.W. (1977). Cyclic nucleotides in the nervous system. Plenum Press, New York.
Dunwiddie, T.V. and Fredholm, B.B (1984). Adenosine receptors mediating inhibitory electrophysical responses in rat hippocampus are different from receptors mediating cyclic AMP accumulation. Naunyn-Schmiedeberg’s Arch. Pharmacol., 326, 294–301.
Fredholm, B.B. (1982). Adenosine receptors. Med. Biol., 60, 289–293.
Fredholm, B.B., Fastbom, J. and Lindgren E. (1986). Effects of Nethylmaleimide and forskolin on glutamate release from rat hippocampal slices. Evidence that prejunctional receptors are linked to N-proteins but not to adenylate cyc:.ase. Acta Physiol. Scand., 127, 381–386.
Fredholm, B.B, Jonzon, B. and Lindström, K. (1986). Effect of adenosine receptor agonists and other compounds on cyclic AMP accumulation in forskolin-treated hippocampal slices. NaunynSchmiedeberg’s Arch. Pharmacol., 332, 173–178.
Fredholm, B.B. and Lindgren, E. (1986). Possible involvement of the Ni-protein in the prejunctional inhibitory effect of a stable adenosine analogue (R-PIA) on noradrenaline release in the rat hippocampus. Acta physiol. scand. 126, 307–309.
Fredholm, B.B., Lindgren, E. and Lindström, K. (1985). Treatment with N-ethylmaleimide selectively reduces adenosine receptor mediated decreases in cyclic AMP accumulation in rat hippocampal slices. Br. J. Pharmacol., 86, 509–513.
Fredholm, B.B., Gustafsson, L.E., Hedqvist, P. and Sollevi, A. (1983). Adenosine in the regulation of neurotransmitter release in the peripheral nervous system. In Regulatory Function of Adenosine. Developments in Pharmacology 2. (eds. R.M. Berne, T.W. Rall and R. Rubio). Martinus Nijhoff Publishers, The Hague.
Fredholm, B.B., Jonzon, B., Lindgren, E. and Lindström, K. (1982). Adenosine receptors mediating cyclic AMP production in the rat hippocampus. J. Neurochem., 39, 165–175.
Hollingsworth, E.B. and Daly, J.W. (1985). Accumulation of inositol phosphates and cyclic AMP in guinea-pig cerebral cortical preparations. Effects of norepinephrine, histamine, carbamylcholine and 2-chloroadenosine. Biochem. Biophys. Acta, 847, 207–216.
Katada, T., Gilman, A.G., Watanabe, Y., Bauer, S. and Jakobs, K.H. (1985). Protein kinase C phosphorylates the inhibitory guaninenucleotide-binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase. Eur. J. Biochem., 151, 431–437.
Laemmli, U.K. (1970). Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680–685.
Londos, C., Cooper, D.M. and Wolff, J. (1980). Subclasses of external adenosine receptors. Proc. Natl. Acad. Sci. U.S.A., 77, 2551–2554.
Nordstedt, C. and Fredholm, B.B. (1986). Phorbol-12,13-dibutyrate enhances the cyclic AMP accumulation in rat hippocampal slices induced by adenosine analogues. Naunyn-Schmiedeberg’s Arch. Pharmacol, in press.
O’Flynn, K., Russul-Saib, M., Ando, I., Wallace, D.L., Beverley, P.C.L., Boylston, A.W. and Linch, D.C. (1986). Different pathways of human T-cell activation revealed by PHA-P and PHA-M. Immunology, 57, 55–60.
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Fredholm, B.B., Nordstedt, C., van der Ploeg, I., Lindgren, E., Ng, J., Jondal, M. (1987). Interactions between the Modulator Adenosine and Classical Transmitters. In: Fuxe, K., Agnati, L.F. (eds) Receptor-Receptor Interactions. Wenner-Gren Center International Symposium Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5415-4_25
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DOI: https://doi.org/10.1007/978-1-4684-5415-4_25
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