Abstract
Thymus-derived lymphocytes (T cells) are essential in the protection of vertebrates from environmental pathogens. As effector cells, they serve to recognize and eliminate cells bearing infectious agents and tumor antigens. In addition, they play a major role in the functional regulation of the immune response. Unlike B lymphocytes, which mediate their antigen-specific functions via secreted or membrane bound immunoglobulins that can bind to soluble ligands, T cells are responsive only to cell-surface antigens. Specifically, T-lymphocyte membrane receptors recognize antigen presenting cells (APCs), which express the autologous class I or class II integral membrane protein products of the major histocompatibility complex (MHC). This interaction between cells can lead to a variety of responses by the antigen-specific T lymphocytes, including proliferation, production of lymphokines, and target cell cytolysis.
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Terhorst, C. et al. (1988). The T-Cell Receptor/T3 Complex on the Surface of Human and Murine T Lymphocytes. In: Mak, T.W. (eds) The T-Cell Receptors. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5406-2_6
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