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MHC-Disease Associations and T Cell-Mediated Immunopathology

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The T-Cell Receptors

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Abstract

Major transplantation antigens coded by the major histocompatibility gene complex (MHC) play a key role in lymphocyte interactions and in immunological recognition. It has become clear over the last 10 years that MHC-gene products (i.e., HLA antigens in humans, H-2 in mice) restrict T-cell specificity or guide T-cell function according to well-established rules (Zinkernagel and Doherty, 1979; Paul and Benacerraf, 1977; Townsend and McMichael, 1984; Möller, 1977); T cells recognise foreign antigens only on cell surfaces and only together with self-transplantation antigens. T-cell function is determined and T-cell responsiveness is regulated by the class of MHC antigens recognised as self. Class I MHC genes (HLA-A,B,C, or H-2K,D,L) regulate activities of class I-restricted, cytotoxic T cells; class II MHC genes (i.e., HLA-D or H-2I) regulate class II-restricted, differentiation-promoting T cells such as helper T cells or T cells involved in delayed type hypersensitivity.

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Authors and Affiliations

  1. Institute for Pathology, University Hospital Zurich, CH-8091, Zurich, Switzerland

    Rolf M. Zinkernagel

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  1. Rolf M. Zinkernagel
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Editors and Affiliations

  1. The Ontario Cancer Institute and Department of Medicine Biophysics and Immunology, University of Toronto, Toronto, Ontario, Canada

    Tak W. Mak

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© 1988 Plenum Press, New York

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Zinkernagel, R.M. (1988). MHC-Disease Associations and T Cell-Mediated Immunopathology. In: Mak, T.W. (eds) The T-Cell Receptors. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5406-2_10

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  • DOI: https://doi.org/10.1007/978-1-4684-5406-2_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5408-6

  • Online ISBN: 978-1-4684-5406-2

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