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Selective Modulation of FSH and LH Secretion by Steroids

  • Chapter
Regulation of Ovarian and Testicular Function

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 219))

Abstract

Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) secreted by the anterior pituitary are important regulators of male and female reproductive processes. The hypothalamic hormone luteinizing hormone releasing hormone (LHRH) has been shown to regulate the release of LH and FSH from the anterior pituitary (Schally et al., 1971). Extensive work has been done on the interaction between gonadal steroids, hypothalamic LHRH and the anterior pituitary in the synthesis and release of LH and this topic has been reviewed by Kalra and Kalra (1983). The regulation of the secretion of FSH, however, cannot be explained adequately with LHRH as the sole regulatory hypothalamic hormone; this is due to a significant divergence between FSH and LH secretion during the ovulatory cycle (Bast and Greenwald, 1974; Smith et al., 1975), after ovariectomy in the rat (Mahesh et al., 1972; Tapper et al., 1972; Zanisi and Martini, 1975a) and during puberty (Dohler and Wuttke, 1975; Payne et al., 1977). This chapter will review the current concepts concerning the role of (a) specific FSH releasing and inhibiting peptides, (b) neuroendocrine control of FSH secretion and (c) steroid hormones in the divergent secretion of FSH and LH.

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Authors and Affiliations

  1. Department of Physiology and Endocrinology, Medical College of Georgia, Augusta, Georgia, 30912, USA

    V. B. Mahesh, L. L. Murphy & J. L. O’Conner

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  1. V. B. Mahesh
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  2. L. L. Murphy
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  3. J. L. O’Conner
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Editors and Affiliations

  1. Medical College Of Georgia, Augusta, Georgia, USA

    Virendra B. Mahesh

  2. National Institutes of Health, Bethesda, Maryland, USA

    Dharam S. Dhindsa

  3. Harvard Medical School, Boston, Massachusetts, USA

    Everett Anderson

  4. University of Florida College of Medicine, Gainesville, Florida, USA

    Satya P. Kalra

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© 1987 Plenum Press, New York

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Mahesh, V.B., Murphy, L.L., O’Conner, J.L. (1987). Selective Modulation of FSH and LH Secretion by Steroids. In: Mahesh, V.B., Dhindsa, D.S., Anderson, E., Kalra, S.P. (eds) Regulation of Ovarian and Testicular Function. Advances in Experimental Medicine and Biology, vol 219. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5395-9_7

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  • DOI: https://doi.org/10.1007/978-1-4684-5395-9_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5397-3

  • Online ISBN: 978-1-4684-5395-9

  • eBook Packages: Springer Book Archive

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