Abstract
The notion that trophic factors are present in the brain and serve to maintain neurons, promote target tissue innervation, and stimulate synaptogenesis has been a well-accepted theory for some time. The transport of trophic factors to neuronal endings has been a favorite explanation for the axonal flow of materials in neurons which was first discovered by Weiss in 1948. More recently, reports of trophic effects of NGF on lesioned CNS neurons and evidence suggesting that insulin and the somatomedins are present in the CNS encouraged us to explore the localization of their receptors. In the experiments described here, we used iodinated human insulin-like growth factor-2 and autoradiography to visualize the receptors for this peptide in rat brain.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Plenum Press, New York
About this chapter
Cite this chapter
Mendelsohn, L.G. (1987). Visualization of IGF-2 Receptors in Rat Brain. In: Raizada, M.K., Phillips, M.I., LeRoith, D. (eds) Insulin, Insulin-like Growth Factors, and Their Receptors in the Central Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5380-5_21
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5380-5_21
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5382-9
Online ISBN: 978-1-4684-5380-5
eBook Packages: Springer Book Archive