Abstract
The action of insulin is initiated by its interaction with the insulin receptor located on the surface of target cells (1). This interaction generates a signal, which when transmitted across the plasma membrane, is propagated and distributed to pleitropic control points of cellular metabolism. Modulation by insulin of flux through these controlled reactions is responsible for regulation of the major energy storage pathways in many cell types. In the adipocyte, glucose uptake, glycogenesis and lipogenesis are accelerated by insulin.
This work was supported by research grants from the National Institute of Health and the Juvenile Diabetes Foundation.
Supported by a postdoctoral fellowship from the Medical Research Council of Canada.
Supported by a postdoctoral fellowship from the National Institutes of Health, USPHS.
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Bernier, M., Frost, S.C., Laird, D.M., Kohanski, R.A., Lane, M.D. (1987). Insulin-Activated Phosphorylation on Tyrosine of a 15 Kilodalton Cytosolic Protein in 3T3-L1 Adipocytes. In: Raizada, M.K., Phillips, M.I., LeRoith, D. (eds) Insulin, Insulin-like Growth Factors, and Their Receptors in the Central Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5380-5_2
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DOI: https://doi.org/10.1007/978-1-4684-5380-5_2
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