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Translational Regulation in the Heat-Shock Response of Drosophila Cells

  • Chapter
Translational Regulation of Gene Expression

Abstract

The heat-shock response has been the subject of intense investigation for several years. The speed of the induction, the magnitude of the response, and the reproducibility of the effect combine to make it an ideal system for investigating mechanisms of gene expression in a wide variety of organisms. In this chapter, I will review current knowledge of translational regulation in the response, focusing on the fruit fly Drosophila melanogaster for two reasons: First, the response of Drosophila cells is the strongest known example of differential gene expression regulated at the translational level. Second, more is known about heat-shock protein synthesis in this organism than in any other.

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Authors and Affiliations

  1. Department of Molecular Genetics and Cell Biology, University of Chicago, Chicago, Illinois, 60637, USA

    Susan Lindquist

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  1. Susan Lindquist
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Editors and Affiliations

  1. Department of Developmental Genetics and Anatomy, School of Medicine, Case Western Reserve University, Cleveland, Ohio, 44106, USA

    Joseph Ilan

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© 1987 Plenum Press, New York

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Lindquist, S. (1987). Translational Regulation in the Heat-Shock Response of Drosophila Cells. In: Ilan, J. (eds) Translational Regulation of Gene Expression. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5365-2_9

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  • DOI: https://doi.org/10.1007/978-1-4684-5365-2_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5367-6

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