Abstract
The clinical aspects of Parkinson’s disease (PD) were first characterized by James Parkinson in 1817 in his monograph “An Essay on Shaking Palsy”. He described the features of the illness as a proneness to tremor with a progressive decline in motor function marked by bradykinesia, rigidity and postural instability (Birkmayer and Riederer, 1983; Klawans and Tanner, 1984). The onset of the illness usually occurs in the sixth or seventh decade and thus, has been considered a disease of aging. Approximately 2 percent of the population over the age of 60 is afflicted with PD and prevalence is predicted to increase with prolonged longevity (Calne, 1970; Marttila, 1983). Neuropathological hallmarks include a loss of dopaminergic neurons in the pars compacta of the substantia nigra (SN) accompanied by a significant decline in the content of dopamine and activity of the synthetic enzyme, tyrosine hydroxylase (Hornykiewicz, 1982; Marsden, 1981). Less pronounced changes involve other neurotransmitter systems including a decline in choline acetyltransferase and glutamic acid decarboxylase activity in the striatum and norepinephrine and dopamine beta hydroxylase activity in the locus coeruleus (Hornykiewicz, 1982). Earlier studies have also reported cortical atrophy associated with an increase in the number of astrocytes, particularly in the frontal cortex, as well as general “senile changes” such as cortical cell loss, neurofibrillary degeneration and senile plaque formations (Turner, 1968).
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References
Aronin, N., DiFiglia, M., Graveland, G.A., Schwartz, W.J., and Wu, J.Y., 1984, Localization of immunoreactive enkephalins in GABA synthesizing neurons of the rat caudate nucleus, Brain Res., 300:376.
Bernheimer, H., Birkmayer, W., Hornykiewicz, O., Jellinger, K., and Seitelberger, F., 1973, Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. J. Neurol. Sci., 20:415.
Birkmayer, W., and Riederer, P., 1983, “Parkinson’s Disease”, Springer-Verlag, Austria.
Buell, S.J., and Coleman, P.D., 1979, Dendritic growth in the aged human brain and failure of growth in senile dementia, Science, 206:854.
Buell, S.J., and Coleman, P.D. 1981, Quantitative evidence for selective dendritic growth in normal human aging but not in senile dementia. Brain Res., 214:23.
Calne, D.B., 1970, “Parkinsonism: Physiology, Pharmacology and Treatment”, Edward Arnold Ltd., London.
Chang, H.T., and Kitai, S.T., 1982, Large neostriatal neurons in the rat: An electron microscope study of gold-toned, Golgi-stained cells, Brain Res. Bull., 8:631.
Coleman, P.D., and Riesen, A.E., 1968, Environmental effects on cortical dendritic fields. I. Rearing in the dark, J. Anat., 102(3):363.
Dimova, R., Vuillet, J., and Seite, R., 1980, Study of the rat neostriatum using a combined Golgi-electron microscope technique and serial sections, Neurosci., 5:1581.
Forno, L.S., and Norville, R.L., 1979, Ultrastructure of neostriatum in Huntington’s and Parkinson’s disease, Adv. Neurol., 23:123
Fox, C.A., Andrade, A.N., Hillman, D.E., and Schwin, R.C., 1971, The spiny neurons in the primate striatum: A Golgi and electron microscopic study, J. Hirnforsch, 13:181.
Freund, T.F., Powell, J.F., and Smith, A.D., 1984, Tyrosine hydroxylase-immunoreactive boutons in synaptic contact with identified striatonigral neurons, with particular reference to dendritic spines, Neurosci., 13(4):1189.
Graybiel, A.M., and Ragsdale, C.W., 1983, Biochemical anatomy of the striatum, in: “Chemical Neuroanatomy”, P.C. Emson, ed., Raven Press, New York.
Groves, P.M., 1980, Synaptic endings and their postsynaptic targets in neostriatum: Synaptic specializations revealed from analysis of serial sections, Proc. Nat’l. Acad. Sci. U.S.A. 77:6926.
Hassler, R., 1938, Zur pathologie der paralysis agitans und des postenzephalitischen Parkinsonismus, J. Psychol. Neurol., 48:387.
Hornykiewicz, O., 1982, Brain neurotransmitter changes in Parkinson’s disease, in: “ Movement Disorders”, C.D. Marsden and S. Fahn, eds., Butterworth Scientific, London.
Jacob, H., 1978, Neuropathologie des Parkinson-Syndroms und die seneszenz des gehirns, in: “Langzeitbehandlung des Parkinson-Syndroms”, P.-A. Fischer, ed., K. Schattauer, Stuttgart-New York.
Jones, W. H., and Thomas, D.B., 1962, Changes in the dendritic organization of neurons in the cerebral cortex following deafferentation, J. Anat. Lond., 96(3) :375.
Kalil, K., 1978, Patch-like termination of thalamic fibers in the putamen of the Rhesus monkey: An autoradiographic study, Brain Res., 140:333.
Kemp, J.M., and Powell, T.P.S., 1970, The cortico-striate projection in the monkey, Brain 93:525.
Kemp, J.M., and Powell, T.P.S., 1971, The termination of fibres from the cerebral cortex and thalamus upon dendritic spines in the caudate nucleus: A study with the Golgi method, Phil. Trans. R. Soc. Lond. B., 262:429.
Kemp, J.M., and Powell, T.P.S., 1971, The structure of the caudate nucleus of the cat: Light and electron microscopy. Phil. Trans. R. Soc. Ser. B., 262:383.
Kemp, J.M., and Powell, T.P.S., 1971, The site of termination of afferent fibers in the caudate nucleus, Phil. Trans. R. Soc. Lond. B., 262:413.
Kish, S.J., Rajput, A., Gilbert, J., Rozdilsky, B., Chang, L-J., Shannk, K. and Hornykiewicz, O., 1986, Eleyated y-aminobutyric acid level in striatal but not extrastriatal brain regions in Parkinson’s disease: correlation with striatal dopamine loss, Ann. Neurol., 20:26.
Klawans, H.L., and Tanner, C.M., 1984, Movement disorders in the elderly, in: “Clinical Neurology of Aging”, M.L. Albert, ed., Oxford University Press, Oxford.
Lehmann, J., and Langer, S.Z., 1983, The striatal cholinergic interneuron: Synaptic target of dopaminergic terminalis? Neurosci., 10(4):1105.
Lloyd, K.G., and O. Hornykiewicz, 1973, L-glutamic acid decarboxylase in Parkinson’s disease: effect of L-dopa therapy, Nature, 243:521.
Lloyd, K.G., and Davidson, L., 1979, Involvement of GABA neurons and receptors in Parkinson’s disease and Huntington’s chorea: a compensatory mechanism?, in: “Advances in Neurology”, P.C. Emson, ed., Raven Press, New York.
Marsden, C.D., 1981, Extrapyramidal diseases, in: “The Molecular Basis of Neuropathology”, A.N. Davison and R.H.S. Thompson, eds., Edward Arnold, London.
Marsden, C.D., 1982, Neurotransmitters and CNS Disease. Basal Ganglia and Aging, The Lancet V. II, 8380:1141.
Marttila, R.J., 1983, Diagnosis and epidemiology of Parkinson’s disease, Acta Neurol. Scand., 95:9.
McGeer, P.L., and McGeer, E.G., 1976, Enzymes associated with the metabolism of catecholamines, acetylcholine and GABA in human controls and patients with Parkinson’s disease and Huntington’s chorea, J. Neurochem., 26:65.
Montfort, J.C., Javoy-Agid, F., Hauw, J.J., Dobois, B. and Agid, Y., 1985, Brain glutamate decarboxylase in Parkinson’s disease with particular reference to a premortem severity index, Brain 108:301.
Moyer, A., V. Moyer, and Coleman, P.D., 1985, An inexpensive PC based system for quantification of neuronal processes, Soc. Neurosci., 11:261.18.
Parkinson, J., 1817, “Essay on the Shaking Palsy”, Neely and Jones, eds., Sherwood, London.
Powell, T.P.S., and Cowan, W.M., 1956, A study of thalamo-striate relations in the monkey, Brain, 79:364.
Rafols, J.A., and Fox, C.A., 1979, Fine structure of the primate striatum, Appl. Neurophysiol, 42:13.
Rajput, A.H., Offord, K.P., Beard C.M., and Kurland, L.T., 1984, Epidemiology of Parkinsonism: incidence, classification, and mortality, Ann. Neurol., 16(3):278.
Reisine, T.D., Fields, J.Z., and Yamamura, H.I., 1977, Neurotransmitter receptor alterations in Parkinson’s disease, Life Sci., 21:335.
Rinne, U.K., 1982, Brain neurotransmitter receptors in Parkinson’s disease, in: “Movement Disorders”, C.D. Marsden and S. Fahn, eds., Butterworth Scientific, London.
Rogers, J., Zornetzer, S.F., Bloom, F.E., and Mervis, R.E., 1984, Senescent microstructural changes in rat cerebellum, Brain Res., 292:23.
Schade, J.P., and Baxter, C.F., 1960, Changes during growth in the volume and surface area of cortical neurons in the rabbit. Exper. Neurol., 2:158.
Schneider, E., Fischer, P.-A., Jacobi, P., and Becker, H., 1978, Zur Relevanz extranigraler Hirnlasionen bei Parkinson-Kranken, in: “Langzeitbehandlung des Parkinson-Syndroms”, P.-A. Fischer, ed., F.K. Schattauer, Stuttgart-New York.
Standler, N.A., and Bernstein, J.J., 1982, Degeneration and regeneration of motoneuron dendrites after ventral root crush:computer reconstruction of dendritic fields, Exper. Neurol., 75:600.
Tretiakoff, C., 1919, Contribution a l’etude de l’anatomie pathologique du locus niger de Sommering avec quelques deductions relatives a la pathogenie des troubles du tonus mulculaire et de la maladie de Parkinson, These med., no 293, Paris.
Trugman, J.M., Geary II, W.A., and Wooten, G.F., 1986. Localization of D-2 dopamine receptors to intrinsic striatal neurones by quantitative autoradiography, Nature, 323:267.
Turner, B., 1968, Pathology of paralysis agitans, in: Diseases of the Basal Ganglia”, P.J. Vinken and G.W. Bruyn, eds., North-Holland Publishing Co., Amsterdam.
Van der Loos, H., 1956, Une combinaison de deux vieilles methodes histologiques pour le systeme nerveux centra, Mschr. Psychiat. Neurol., 132:330.
Wilson, C.J., and P.M. Groves, P.M., 1980, Fine structure and synaptic connections of the common spiny neuron of the rat neostriatum: A study employing intracellular injection of horseradish peroxidase, J. Comp. Neurol., 194:599.
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© 1987 Plenum Press, New York
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McNeill, T.H., Brown, S.A., Shoulson, I., Lapham, L.W., Eskin, T.A., Rafols, J.A. (1987). Regression of Striatal Dendrites in Parkinson’s Disease. In: Carpenter, M.B., Jayaraman, A. (eds) The Basal Ganglia II. Advances in Behavioral Biology, vol 32. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5347-8_34
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DOI: https://doi.org/10.1007/978-1-4684-5347-8_34
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