Abstract
Specific mucosal defense mechanisms involve the mobilization of the secretory immune system. Even in a healthy individual, secretory immunity is involved in host-bacterial interactions at colonized mucosal surfaces. For example, in the oral cavity of SPF-inbred mice, the colonization and the growth of indigenous bacteria are under the continuous influence of salivary IgA antibodies (1,2). Conversely, it appears that, under normal conditions, the indigenous flora can effectively sensitize the secretory immune system. It is possible that the availability of oral microbial antigens, via retrograde passage through the secretory ducts of minor salivary glands (MSGs) (3), could potentiate IgA antibody production by inducing further proliferation and differentiation of GALT-derived precursor cells (4).
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© 1987 Plenum Press, New York
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Lacasse, M., Collet, A., Mourad, W., Deslauriers, N. (1987). Incidence and Distribution of Immunocytes in the Murine Oral Mucosa. In: Mestecky, J., McGhee, J.R., Bienenstock, J., Ogra, P.L. (eds) Recent Advances in Mucosal Immunology. Advances in Experimental Medicine and Biology, vol 216 A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5344-7_43
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DOI: https://doi.org/10.1007/978-1-4684-5344-7_43
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