Skip to main content
SpringerLink
Log in

Antigen Presentation by Gut Epithelial Cells: Secretion by Rat Enterocytes of a Factor with IL-1-Like Activity

  • Chapter
Recent Advances in Mucosal Immunology

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 216 A))

Abstract

Evidence is emerging that the epithelial interface of the gut may play an important role in directing the type of immune response initiated towards enteric antigens. Soluble protein antigens are processed to constituent antigenic peptides during absorption from the lumen (1) and such processing may give rise to circulating fragments with greater tolerogenicity than the native protein (2). In addition to its antigen processing function, the epithelium may be directly involved in the presentation of absorbed antigen, and the local induction of immunoregulatory lymphocytes. Thus, fully differentiated absorptive epithelial cells (EC) isolated from the rat small intestine can present soluble protein antigens to immune lymph node T cells in vivo (3), causing them to proliferate and differentiate into antigen-specific suppressor cells (4).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Stem, M. and Walker, W.A., Am. J. Physiol. 246, G556, 1984.

    Google Scholar 

  2. Bruce, M.G. and Ferguson, A., Immunology 57, 627, 1986.

    PubMed  CAS  Google Scholar 

  3. Bland, P.W. and Warren, L.G., Immunology 58, 1, 1986.

    PubMed  CAS  Google Scholar 

  4. Bland, P.W. and Warren, L.G., Immunology 58, 9, 1986.

    PubMed  CAS  Google Scholar 

  5. Ziegler, K. and Unanue, E., J. Immunol. 127, 1869, 1981.

    PubMed  CAS  Google Scholar 

  6. Lee, K.C., Wilkinson, A. and Wong, M., Cell. Immunol. 48, 79, 1979.

    Article  PubMed  CAS  Google Scholar 

  7. Kaye, J., Gillis, S., Mizel, S.B., Shevach, E.M., Males, T.R., Dinarello, C.A., Lachman, L.B. and Janeway, C.A., J. Immunol. 133, 1339, 1984.

    PubMed  CAS  Google Scholar 

  8. Luger, T.A., Stadler, B.M., Katz, S.I. and Oppenheim, J.J., J. Immunol. 127, 1493, 1981.

    PubMed  CAS  Google Scholar 

  9. Fontana, A., Kristensen, F., Dubs, R., Gemsa, D. and Weber, E., J. Immunol. 129, 2413, 1982.

    PubMed  CAS  Google Scholar 

  10. Lovett, D.H., Ryan, J.L. and Sterzel, R.B., J. Immunol. 130, 1796, 1983.

    PubMed  CAS  Google Scholar 

  11. Roska, A.K., Johnson, A.R. and Lipsky, P.E., J. Immunol. 132, 136, 1984.

    PubMed  CAS  Google Scholar 

  12. Matsushima, K., Procopio, A., Abe, H., Scala, G., Ortaldo, J.R. and Oppenheim, J.J., J. Immunol. 135, 1132, 1985.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Veterinary Medicine, University of Bristol, Langford House, Langford, Bristol, BS18 7DU, UK

    P. W. Bland

Authors
  1. P. W. Bland
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Alabama at Birmingham, Birmingham, Alabama, USA

    Jiri Mestecky  & Jerry R. McGhee  & 

  2. McMaster University, Hamilton, Ontario, Canada

    John Bienenstock

  3. State University of New York at Buffalo, Buffalo, New York, USA

    Pearay L. Ogra

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Plenum Press, New York

About this chapter

Cite this chapter

Bland, P.W. (1987). Antigen Presentation by Gut Epithelial Cells: Secretion by Rat Enterocytes of a Factor with IL-1-Like Activity. In: Mestecky, J., McGhee, J.R., Bienenstock, J., Ogra, P.L. (eds) Recent Advances in Mucosal Immunology. Advances in Experimental Medicine and Biology, vol 216 A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5344-7_25

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5344-7_25

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5346-1

  • Online ISBN: 978-1-4684-5344-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation