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Mechanisms of Lymphocyte Activation and Immune Regulation pp 189–193Cite as

Transmembrane Signaling Reactions Generated in B Cells in Response to ANTI-IgM or Lipopolysaccharide

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 213))

Abstract

The development and activation of B lymphocytes appear to be highly regulated by antigen or other agents interacting with mIgM and mIgD, products of helper T cells and macrophages, complement fragments, and bacterial products such as lipopolysaccharide (LPS) (1,2). One approach toward understanding this rich complexity is to define how the B cell translates these extracellular signals into intracellular biochemical reactions that may contribute to the regulation of growth and development of the cell. The recent work on signal transduction from membrane IgM and from the putative receptor for LPS are described.

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Author information

Authors and Affiliations

  1. Department of Microbiology and Immunology and the G.W. Hooper Foundation, University of California, San Francisco, CA, 94143, USA

    Anthony L. DeFranco

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  1. Anthony L. DeFranco
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Editor information

Editors and Affiliations

  1. University of California, Irvine, California, USA

    Sudhir Gupta

  2. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

    William E. Paul  & Anthony S. Fauci  & 

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© 1987 Plenum Press, New York

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DeFranco, A.L. (1987). Transmembrane Signaling Reactions Generated in B Cells in Response to ANTI-IgM or Lipopolysaccharide. In: Gupta, S., Paul, W.E., Fauci, A.S. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation. Advances in Experimental Medicine and Biology, vol 213. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5323-2_18

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  • DOI: https://doi.org/10.1007/978-1-4684-5323-2_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5325-6

  • Online ISBN: 978-1-4684-5323-2

  • eBook Packages: Springer Book Archive

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