Abstract
B cells, which are responsible for the secretion of antibodies, originate from pluripotent hematopoietic stem cells and differentiation stages, such as pre-B cells, mature B cells, activated B cells and antibody secreting cells. The commitment of each B cell clone to a specific antigen occurs at the pre-B cell level and mature B cells express IgM molecules as antigen receptors on their surface. Binding of an antigen complementary to the receptors of a certain B cell clone initiates a complex series of the activation process resulting into antibody secreting cells. This process of clonal expansion and differentiation requires the collaboration of helper T cells. Recently, the T cell-dependent activation process of B cells into antibody secreting cells has been extensively studied and the involvement of B cell specific growth and differentiation factors in this process has been demonstrated (1,2). The results are schematically summarized in Fig. 1.
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© 1987 Plenum Press, New York
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Kishimoto, T., Hirano, T., Kikutani, H., Muraguchi, A. (1987). Delineation of Human B Cell Differentiation: Immunological and Molecular Characterization of Human B Cell Differentiation Factor (BSF-2). In: Gupta, S., Paul, W.E., Fauci, A.S. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation. Advances in Experimental Medicine and Biology, vol 213. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5323-2_17
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DOI: https://doi.org/10.1007/978-1-4684-5323-2_17
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