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The Multiple Biological Properties of Interleukin-1 Influencing Immunocompetent Cells

  • Chapter
Mechanisms of Lymphocyte Activation and Immune Regulation

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 213))

Abstract

The acute phase response is a systemic, generalized reaction despite the fact that most disease processes which induce circulating IL-1 produced at the site of the disease, for example, the lung in pneumonia. Once released into the circulation, IL-1 acts on multiple target organs and induces a variety of biological changes. Considerable attention has also focused on the local production and activity of IL-1. Local concentrations of IL-1 in specialized tissues such as the skin, kidney, endothelium, lymph node and joint space may account for much of its role in disease processes. The role of IL-1’s in acute phase responses will be matched by interest in its effects on bone and cartilage destruction as well as the pathogenesis of arthrosclerosis. The ability of the various IL-1’s to activate lymphocytes, induce the synthesis of acute phase proteins, alter various metabolic and hematologic parameters and to produce fever and sleep has provided the evidence that IL-1’s are more than interleukins but rather multifunctional molecules capable of acting on different cells types.

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  1. From the Department of Medicine, Tufts University School of Medicine, Boston, Massachusetts, 02111, USA

    Charles A. Dinarello

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  1. University of California, Irvine, California, USA

    Sudhir Gupta

  2. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

    William E. Paul  & Anthony S. Fauci  & 

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Dinarello, C.A. (1987). The Multiple Biological Properties of Interleukin-1 Influencing Immunocompetent Cells. In: Gupta, S., Paul, W.E., Fauci, A.S. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation. Advances in Experimental Medicine and Biology, vol 213. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5323-2_10

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