Abstract
Since Ca-action potentials were first measured in β-cells, it has been assumed that the resultant Ca2+ influx provides a critical Ca2+-dependent step in the events leading to insulin secretion.4,6. The correlation between electrical activity and insulin release remained indirect, however, since membrane potentials were recorded from single β-cells within an isolated islet and insulin release was measured from batches of collagenase isolated islets (usually more than 100) or from the perfused pancreas (containing over 1000 islets).
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References
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© 1986 Plenum Press, New York
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Rosario, L.M., Atwater, I., Scott, A.M. (1986). Pulsatile Insulin Release and Electrical Activity from Single ob/ob Mouse Islets of Langerhans. In: Atwater, I., Rojas, E., Soria, B. (eds) Biophysics of the Pancreatic β-Cell. Advances in Experimental Medicine and Biology, vol 211. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5314-0_40
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DOI: https://doi.org/10.1007/978-1-4684-5314-0_40
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