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Interdependency of Ca2+ Availability and Cyclic AMP Generation in the Pancreatic β-Cell

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Biophysics of the Pancreatic β-Cell

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 211))

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Abstract

At least ten distinct coupling factors or second messengers may participate in the process of insulin release from the pancreatic β-cell. They include, inter alia, reducing equivalents, protons, ATP, diacylglycerol, inositol 1,4,5-triphosphate, polyamine and obviously cyclic AMP and cytosolic ionized calcium. This report deals briefly with the inter-dependency of Ca2+ availability and cyclic AMP generation in the pancreatic β-cell.

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References

  1. P. Garcia-Morales, S.P. Dufrane, A. Sener, I. Valverde, and W.J. Malaisse, Inhibitory effect of Clonidine upon adenylate cyclase activity, cyclic AMP production, and insulin release in rat pancreatic islets, Biosci. Reports 4:511 (1984).

    Article  CAS  Google Scholar 

  2. V. Leclercq-Meyer, A. Herchuelz, I. Valverde, E. Couturier, J. Marchand and W.J. Malaisse, Mode of action of Clonidine upon islet function. Dissociated effects upon the time course and magnitude of insulin release, Diabetes 29:193 (1980).

    Article  PubMed  CAS  Google Scholar 

  3. W.J. Malaisse, P. Garcia-Morales, S.P. Dufrane, A. Sener, and I. Valverde, Forskolin-induced activation of adenylate cyclase, cyclic adenosine monophosphate production and insulin release in rat pancreatic islets, Endocrinology 115:2015 (1984)..

    Article  PubMed  CAS  Google Scholar 

  4. W.J. Malaisse and F. Malaisse-Lagae, The role of cyclic AMP in insulin release, Experientia 40:1068 (1984).

    Article  PubMed  CAS  Google Scholar 

  5. W.J. Malaisse, Y. Scholler, and V. De Maertelaer, Mathematical modelling of stimulus-secretion coupling in the pancreatic β-cell. Dissociated time course for the glucose-induced changes in distinct Ca2+ movements, Diabetes Res. 2:195 (1985).

    PubMed  CAS  Google Scholar 

  6. W.J. Malaisse, M. Svoboda, S.P. Dufrane, F. Malaisse-Lagae, and J. Christophe, Effect of Bordetella pertussis toxin on ADP-ribosylation of membrane proteins, adenylate cyclase activity and insulin release in rat pancreatic islets, Biochem. Biophys. Res. Commun. 124:190 (1984).

    Article  PubMed  CAS  Google Scholar 

  7. W.J. Malaisse, I. Valverde, A. Owen, D. Verhulst and F. Cantraine, Mathematical modelling of cyclic AMP-Ca2+ interactions in pancreatic islets, Diabetes 31:170 (1982).

    Article  PubMed  CAS  Google Scholar 

  8. Y. Scholler, V. De Maertelaer, and W.J. Malaisse, Mathematical modelling of stimulus-secretion coupling in the pancreatic β-cell. I. Dynamics of insulin release, Acta Diabet. Lat. 20:329 (1983).

    Article  CAS  Google Scholar 

  9. Y. Scholler, V. De Maertelaer, and W.J. Malaisse, Mathematical modelling of stimulus-secretion coupling in the pancreatic β-cell. II. Calcium-stimulated calcium release, Computers Prog. in Biomed. 19:119 (1985).

    Article  CAS  Google Scholar 

  10. Y. Scholler, V. De Maertelaer, and W.J. Malaisse, Mathematical modelling of stimulus-secretion coupling in the pancreatic β-cell. III. Glucose-induced inhibition of calcium efflux, Biophys. J. 46:439 (1984).

    Article  PubMed  CAS  Google Scholar 

  11. M. Svoboda, P. Garcia-Morales, S.P. Dufrane, A. Sener, I. Valverde, J. Christophe, and W.J. Malaisse, Stimulation by cholera-toxin of ADP-ribosylation of membrane proteins, adenylate cyclase and insulin release in pancreatic islets, Cell. Biochem. Funct. 3:25 (1985).

    Article  PubMed  CAS  Google Scholar 

  12. I. Valverde, P. Garcia-Morales, M. Ghiglione, and W.J. Malaisse, The stimulus-secretion coupling of glucose-induced insulin release. LIII. Calcium dependency of the cyclic AMP response to nutrient secretagogues, Horm. Metab. Res. 15:62 (1983).

    Article  PubMed  CAS  Google Scholar 

  13. I. Valverde and W.J. Malaisse, Calmodulin and pancreatic β-cell function, Experientia 40:1061 (1984).

    Article  PubMed  CAS  Google Scholar 

  14. I. Valverde, A. Sener, P. Lebrun, A. Herchuelz, and W.J. Malaisse, The stimulus-secretion coupling of glucose-induced insulin release. XLVII. The possible role of calmodulin, Endocrinology 108:1305 (1981).

    Article  PubMed  CAS  Google Scholar 

  15. I. Valverde, A. Vandermeers, R. Anjaneyulu, and W.J. Malaisse, Calmodulin activation of adenylate cyclase in pancreatic islets, Science 206:225 (1979).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Madrid, Spain

    I. Valverde, P. Garcia-Morales, M. Saceda & W. J. Malaisse

  2. Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium

    I. Valverde, P. Garcia-Morales, M. Saceda & W. J. Malaisse

Authors
  1. I. Valverde
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  2. P. Garcia-Morales
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  3. M. Saceda
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  4. W. J. Malaisse
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Editor information

Editors and Affiliations

  1. National Institutes of Health, Bethesda, Maryland, USA

    Illani Atwater  & Eduardo Rojas  & 

  2. University of Alicante, Alicante, Spain

    Bernat Soria

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© 1986 Plenum Press, New York

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Valverde, I., Garcia-Morales, P., Saceda, M., Malaisse, W.J. (1986). Interdependency of Ca2+ Availability and Cyclic AMP Generation in the Pancreatic β-Cell. In: Atwater, I., Rojas, E., Soria, B. (eds) Biophysics of the Pancreatic β-Cell. Advances in Experimental Medicine and Biology, vol 211. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5314-0_38

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  • DOI: https://doi.org/10.1007/978-1-4684-5314-0_38

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5316-4

  • Online ISBN: 978-1-4684-5314-0

  • eBook Packages: Springer Book Archive

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