Abstract
In addition to its highly specific requirement for glucose as a substrate, the brain, unlike some other tissues, contains relatively little of the glucose storage form, glycogen. Thus the brain is critically dependent on a continued supply of blood-borne glucose and oxygen to maintain neurological function. This strict reliance on aerobic glucose metabolism is reflected in the organization of relevant enzymes in the brain.
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Felgner, P.L., Messer, J.L., and Wilson, J.E., 1979, J. Biol. Chem. 254:4946.
Fiek, C., Benz, R., Roos, N. and Brdiczka, D., 1982, Biochim. Biophys. Acta, 688:429.
Johnson, M.K., 1960, Biochem. J., 77:610.
Linden, M., Gellerfors, P., and Nelson, B.D., 1982, FEBS Lett. 141:189.
Lowry, O.H., Roberts, N.R., Schulz, D.W., Clow, J.E., and Clark, J.R., 1961, J. Biol. Chem., 236:2813.
Pette, D., 1975, Acta Histochem. Supplementary Vol. 14, 47.
Rose, I.A. and Warms, J.V.B., 1967, J. Biol. Chem. 242:1635.
Staudte, H.W., and Pette, D., 1972, Comp. Biochem. Physiol., 41B:533.
Wilson, J.E., 1972, J. Neurochem. 19:223.
Wilson, J.E., 1985, In: “Regulation of Carbohydrate Metabolism”, R. Beitner, ed., CRC Press, Boca Raton, FL.
Wilson, J.E. and Feigner, P.L., 1977, Mol. Cell. Biochem., 18:39.
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© 1986 Plenum Press, New York
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Wilson, J.E. (1986). Mitochondrial Hexokinase: Interactions between Glycolysis and Oxidative Phosphorylation. In: Welch, G.R., Clegg, J.S. (eds) The Organization of Cell Metabolism. NATO ASI Series, vol 127. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5311-9_16
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DOI: https://doi.org/10.1007/978-1-4684-5311-9_16
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