Abstract
Contemplation of the sheer complexity of cellular metabolism, coupled with the realization that in bacterial cells it all takes place in a minute volume exhibiting a minimum of cellular architectural detail, soon begins to prompt questions about the nature of intracellular organization in prokaryotic cells. The very absence of membrane-bounded organelles suggests that, aside from reactions localized in or about the cell membrane, organizational structure is likely to be based on direct macromolecular interactions. These would yield macro structures which in some cases might also act in a more-or-less compartmentalized fashion, leading to the separate channelling of whole series of sequential reactions. There is some variation in the way in which the terms “compartment” and “channel” are used. In the present contribution a “channel” is defined as a structure or a facet of organization which acts as a constraint to free chemical diffusion. A “compartment” is a sequestered volume; it may be similar to a channel. Any defined aspect of biochemical organization may represent a compartment so long as it remains chemically inactive. For example, a ligand bound to an enzyme is in a compartment until it undergoes a reaction.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Atkinson, D.E., 1969, Curr, Top Cell. Regul., 1:29.
Barnes, S. and Weitzman, P.D.J., 1985, This volume.
Bearden, L. and Moses, V., 1972, Biochim. Biophys. Acta., 279:513.
Gamper, H. and Moses, V., 1974, Biochim. Biophys. Acta, 354:75.
Garrib, A., 1983, Ph.D. Thesis, University of London: “The enzymes of proline biosynthesis in Escherichia coli and Proteus mirabillis”.
Gorringe, D.M. and Moses, V., 1980, Int. J. Biol. Macromol., 2:161.
Hayzer, D.J. and Moses, V., 1978, Biochem. J., 173:219.
Katchalsky, A. and Paecht, M., 1954, J. Amer. Chem. Soc., 76:6042.
Kingdon, C.F.M., 1983, Ph.D. Thesis, University of London: “The status of glycolytic organization in Escherichia coli”.
Ling, G.N. and Cope, F.W., 1969, Science. 163:1335.
Macnab, R., Moses, V. and Mowbray, J., 1973, Eur. J. Biochem., 34:15.
Manney, T.R., 1970, J. Bacteriol.. 102:483.
McBrien, D.C.H. and Moses, V., 1968, J. Gen. Microbiol., 51:159.
Moses, V. and Lonberg-Holm, K.K., 1968, J. Theor. Biol., 10:336.
Mowbray, J. and Moses, V., 1976, Eur. J. Biochem.. 66:25.
Pflugfelder, M., Adams, B., and Kirschner, K., 1985, Abstracts of the 24th Harden Conference, 19.
Sols, A. and Marco, R., 1970, Curr, Top Cell. Regul., 2:227.
Strecker, H.J., 1960. J. Biol. Chem., 235:2045.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this paper
Cite this paper
Moses, V. (1986). Implications of Metabolic Compartmentation in Prokaryotic Cells. In: Welch, G.R., Clegg, J.S. (eds) The Organization of Cell Metabolism. NATO ASI Series, vol 127. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5311-9_12
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5311-9_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5313-3
Online ISBN: 978-1-4684-5311-9
eBook Packages: Springer Book Archive