Organization of Enzymes in the Tryptophan Pathway

DeMoss, John A.

doi:10.1007/978-1-4684-5311-9_11

John A. DeMoss³

Part of the book series: NATO ASI Series ((NSSA,volume 127))

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Abstract

The reactions which constitute the pathway for tryptophan biosynthesis exhibit an unusual degree of organizational diversity throughout the biological world. The component reactions of this pathway, including those involved in general aromatic biosynthesis, are organized in different patterns of multifunctional complexes; and this diversity is reflected in specific patterns of gene-enzyme relationships. Some of the first reported examples of multifunctional proteins and channelling of intermediates between active sites in multifunctional proteins were uncovered by the extensive biochemical and genetic studies of this pathway. To illustrate the organization of active sites in multifunctional protein complexes, I will review several well-defined examples from this pathway. In this review my emphasis will be on the current status of our understanding of the structure of multifunctional enzymes and the possible functional role of enzyme organization within this pathway.

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Department of Biochemistry and Molecular Biology, University of Texas Health Science Center at Houston, Houston, Texas, 77005, USA
John A. DeMoss

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John A. DeMoss
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Editors and Affiliations

University of New Orleans, New Orleans, Louisiana, USA
G. Rickey Welch
University of California, Davis, Davis, California, USA
James S. Clegg

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DeMoss, J.A. (1986). Organization of Enzymes in the Tryptophan Pathway. In: Welch, G.R., Clegg, J.S. (eds) The Organization of Cell Metabolism. NATO ASI Series, vol 127. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5311-9_11

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DOI: https://doi.org/10.1007/978-1-4684-5311-9_11
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5313-3
Online ISBN: 978-1-4684-5311-9
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