Abstract
A variety of factors influence neuronal survival and differentiation in culture systems. Since neurons are post-mitotic with only rare exceptions, neurons are not acted upon by mitogens. The factors which have been described to date divide naturally into three categories: factors which influence survival in culture, factors which influence substrate attachment and neurite outgrowth, and factors which influence biochemical differentiation[1]. The biological role in vivo of only one, NGF (nerve growth factor), has received experimental support[2].
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© 1987 Plenum Press, New York
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Gurney, M.E., Apatoff, B.R., Heinrich, S.P. (1987). Purification of a Survival Factor for Spinal Neurons from Mouse Salivary Gland. In: Cosi, V., Kato, A.C., Parlette, W., Pinelli, P., Poloni, M. (eds) Amyotrophic Lateral Sclerosis. Advances in Experimental Medicine and Biology, vol 209. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5302-7_8
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DOI: https://doi.org/10.1007/978-1-4684-5302-7_8
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