Abstract
After lesion of a peripheral nerve there is a complex of histometabolic reactions that occurs in the cell body and dendritic tree. Some changes are even observable at the light microscopic level and were termed chromatolysis. In summary, the reaction is characterized by dissolution of the basophilic granules, rounding of the perikaryon, enlargement of the nucleolus, and dispersal of the Nissl substance. The latter corresponds to the disaggregation of cytoplasmic ribosomal clusters and deagranulation of the rough endoplasmic reticulum. This process is inhibited if actinomycin D is injected at the time of the axonal damage or within 9 hours, suggesting the involvement of RNA synthesis as a trigger for chromatolytic reaction[l]. It is a fact that regenerating neurons produce more proteins, even at faster rates, as shown by many laboratories (see other chapters in ref.[l]).
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Gorio, A. (1987). The Role of Axoplasmic Transport in the Restoration of Synaptic Transmission and in the Process of Sprouting During Nerve Regeneration. In: Cosi, V., Kato, A.C., Parlette, W., Pinelli, P., Poloni, M. (eds) Amyotrophic Lateral Sclerosis. Advances in Experimental Medicine and Biology, vol 209. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5302-7_7
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