Abstract
N-acetylcysteine (NAC) and Dithiothreitol (DTT), two compounds that prevent experimental amyotrophic lateral sclerosis (ALS) in the vitamin C - deficient guinea pig[1], were given to patients with motor neuron disease (MND). These patients were accepted regardless of the stage of their illness, promised uninterrupted treatment, instructed to come for monthly out-patient visits, forbidden the use of the NAC-antagonists phenacetin and acetaminophen and left free to continue any other mode of attempted therapy.
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References
W. A. den Hartog Jager, Experimental amyotrophic lateral sclerosis in the guinea pig, J.Neurol.Sci., 67: 133–142 (1985).
F. H. Norris, Jr., P. R. Calanchini, R. J. Fallat, S. Panchari, and B. Jewett, The administration of guanidine in amyotrophic lateral sclerosis, Neurology (Minneap.), 24: 721–8 (1974).
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© 1987 Plenum Press, New York
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de Jong, J.M.B.V., den Hartog Jager, W.A., Vyth, A., Timmer, J.G. (1987). Attempted Treatment of Motor Neuron Disease with N-Acetylcysteine and Dithiothreitol. In: Cosi, V., Kato, A.C., Parlette, W., Pinelli, P., Poloni, M. (eds) Amyotrophic Lateral Sclerosis. Advances in Experimental Medicine and Biology, vol 209. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5302-7_39
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DOI: https://doi.org/10.1007/978-1-4684-5302-7_39
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5304-1
Online ISBN: 978-1-4684-5302-7
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