Abstract
The immune system may be able to contribute to the pathogenesis of ALS as it has to other neurological diseases such as experimental allergic encephalomyelitis, multiple sclerosis and lymphocytic choriomeningitis. The selective damage to upper and lower motor neurons in ALS might be regarded as a feature of a brain-confined, organ-specific autoimmune disease. The greater frequency of some histocompatibility antigens (HLA3, HLB12, HLBW35) may suggest the possible predisposition to autoimmune and infectious diseases [1-3].
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
J. P. Antel, B. G. W. Arnason, T. C. Fuller, and J. R. Lehrich, Histocompatibility typing in amyotrophic lateral sclerosis, Arch.Neurol, 33: 423–425 (1976).
E. Kott, E. Livni, R. Zamir, and A. Kuritzky, Amyotrophic lateral sclerosis: cell-mediated immunity to poliovirus and basic myelin protein in patients with high frequency of HLA-BW35, Neurology, 26: 376–377 (1976).
P. O. Behan, H. M. Dick, and W. F. Durward, Histocompatibility antigens associated with motor neuron disease, J.Neurol.Sci., 32: 213–217 (1976).
J. N. Whitaker, J. Sciabbarrasi, and W. K. Engel, Serum immune globulins and complement (C3) levels: a study in adults with idiopatic chronic polyneuropathies and motor neuron diseases, Neurology, 23: 1164 - 1173 (1973).
M. B. A. Oldstone, L. H. Perrin, C. B. Wilson, and F. H. Norris, Evidence for immune-complex formation in patients with amyotrophic lateral sclerosis, Lancet, 24: 169 (1976).
B. F. Tavolato, A. C. Licandro, and A. Saia, Motor neuron disease: an immunological study, Eur.Neurol. 13: 433 - 440 (1975).
E. H. Denys, E. K. Bjornskow, J. E. Jackson, and F. H. Norris, Anti- nuclear antibodies in amyotrophic lateral sclerosis, in: “Trends in ALS Research,” A. Struppler and G. Kuther, eds., pp. 49–59 (1983).
E. Kott, E. Livni, R. Zamir, and A. Kuritzky, Cell-mediated immunity to polio and HLA antigens in amyotrophic lateral sclerosis, Neurology, 29: 1040–1044 (1979).
N. E. Cremer, F. H. Norris, and T. Shinomoto, Antibody titers to cox sackieviruses in amyotrophic lateral sclerosis, New Eng.J.Med., 295: 107–108 (1976).
F. Wolfgram and L. Myers, Amyotrophic lateral sclerosis: effect of serum on anterior horn cells in tissue culture, Science, 179: 579–580 (1973).
R. P. Lisak, B. Awiman, and M. Norman, Antimyelin antibodies in neuro logic diseases, Arch.Neurol., 32: 163–167 (1975).
M. B. A. Oldstone, L. H. Perrin, and R. M. Welsh, Potential pathogenic mechanisms of injury in amyotrophic lateral sclerosis, in: “Amyotrophic Lateral Sclerosis, Recent Research Trends,” J. M. Andrews, R. T. Johnson, and M. A. Brazier, eds., Academic Press, New York, p. 251 (1976).
H. L. Weiner, A. L. Schoeket, and J. A. Lehrich, Lymphocytotoxic anti bodies in subacute sclerosing panencephalitis and amyotrophic lateral sclerosis, Lancet, 1: 1013 (1977).
M. E. Gurney, A. C. Belton, N. Cashman, and J. P. Antel, Inhibition of terminal axonal sprouting by serum from patients with amyotrophic lateral sclerosis, New Eng.J.Med., 311: 933–939 (1984).
J. P. Antel M. Weinrich, and B. G. W. Arnason, Circulating suppressor cells in a man as a function of age, Clin.Immunol.Immunopath., 9: 134–141 (1978).
L. Shou, S. A. Schwartz, and R. A. Good, Suppressor cell activity after Concanavalin A treatment of lymphocytes from normal donors, J.Exp.Med., 143: 1100 (1976).
P. H. Hoffman, D. S. Robbins, M. T. Nolte, C. J. Gibbs, and D. C. Gajdusek, Cellular immunity in amyotrophic lateral sclerosis and Parkinsonism-dementia, New Eng.J.Med., 299: 680–685 (1978).
J.P. Antel, A. B. C. Noronha, J. J. F. Oger, and B. G. W. Arnason, Immunology of amyotrophic lateral sclerosis, in: “Human Motor Neuron Diseases,” L. P. Rowland, ed., Raven Press, New York, pp. 395–402 (1982).
G. J. Nemo, J. A. Brody, and M. Cruz, Lymphocytic transformation study of Guaiaman patients with amyotrophic lateral sclerosis and Parkinsonism-dementia, Neurology, 24: 579–581 (1974).
J. P. Antel, D. P. Richman, and B. G. W. Arnason, Immunogenetics and amyotrophic lateral sclerosis, in: “Amyotrophic Lateral Sclerosis, Recent Research Trends,” J. M. Andrews, R. T. Johnson, and M. A. Braxier, eds., Academic Press, New York, p. 145 (1976).
J. P. Antel, M. E. Medof, D. P. Richman, and B. G. W. Arnason, Immunological consideration in amyotrophic lateral sclerosis, in: “Clinical Neuroimmunology,” Clifford Rose, ed., Blackwell Scientific Publications, pp. 227 - 244 (1979).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Plenum Press, New York
About this chapter
Cite this chapter
Provinciali, L., Giovagnoli, A.R., Battucci, S., Bartocci, C., Montroni, M. (1987). Immunological Assessment in Sporadic Amyotrophic Lateral Sclerosis (ALS). In: Cosi, V., Kato, A.C., Parlette, W., Pinelli, P., Poloni, M. (eds) Amyotrophic Lateral Sclerosis. Advances in Experimental Medicine and Biology, vol 209. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5302-7_25
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5302-7_25
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5304-1
Online ISBN: 978-1-4684-5302-7
eBook Packages: Springer Book Archive