Abstract
The etiology and pathogenesis of amyotrophic lateral sclerosis are still in debate. Among various hypotheses from different laboratories, some in vitro studies have discussed the possibility of the presence of a deleterious factor (or factors) in the serum of ALS patients against cultured spinal cord explants[1-3]. Other workers could not confirm such findings[4-6]. The potential significance of such a possibility and the discrepancy between the results of these studies have motivated us to address the same question, with some difference in the employed techniques as described below.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
F. Wolfgram and L. Meyers, Trans.Am.Neurol.Assoc., 97: 19–23 (1972).
F. Wolfgram and L. Meyers, Science, 179: 579–580 (1973).
F. Roisen, H. Bartfeld, H. Donnefeld, and J. Baxter, Muscle and Nerve, 5: 48–53 (1982).
M. Howrich, K. Engel, and B. Chauvin, Acta Neuropath., 32: 127–131 (1974).
J. Liveson, H. Frey, and M. Bornstein, Acta Neuropath., 32: 127–131 (1975).
J. R. Lehrich and J. Lacouture, Ann.Neurol., 41: 384–385 (1978).
B. Festoff, Med.Hypoth., 6: 121–132 (1980).
J. B. Cavanaugh, Int.Rev.Exp.Path., 3: 219–267 (1966).
A. Oldstone, B. Wilson, D. Dalessio, F. Norris, and E. Nelson, Trans. Am.Neurol.Assoc., 98: 31–32 (1973).
G. Wohlfart, Neurology, 7: 124–130 (1957).
A. Hirano and M. Iwata, in: “Proc. Int. Symp.”, Tsubaki and Toyokura, eds., Univ. Tokyo Press (1979).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1987 Plenum Press, New York
About this chapter
Cite this chapter
Maher, I., Pouplard-Barthelaix, A., Emile, J. (1987). Cytotoxicity of Serum from Amyotrophic Lateral Sclerosis Patients on Spinal Cord Cells in Culture. In: Cosi, V., Kato, A.C., Parlette, W., Pinelli, P., Poloni, M. (eds) Amyotrophic Lateral Sclerosis. Advances in Experimental Medicine and Biology, vol 209. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5302-7_12
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5302-7_12
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5304-1
Online ISBN: 978-1-4684-5302-7
eBook Packages: Springer Book Archive