Abstract
In the broadest sense of the word, a toxicant is any substance that causes changes in the function, structure, or replication of cells or the maintenance of homeostasis in a tissue of any living organism. Ordinarily, a toxicant is considered to be a substance in the environment that gains entrance into the body by inhalation, ingestion, injection, or absorption. But a toxicant may also be formed within the organism. Indeed, it may be a neurotransmitter, a hormone, or a metabolic acid that at low concentrations plays a vitally important role in maintaining the wellbeing of the organism, but at higher concentrations triggers an abnormal response.
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References
Boyd, M. R., and L. T. Buka. 1978. In vivo studies on the relationship between target organ alkylation and the pulmonary toxicity of a chemically reactive metabolite of 4-ipomeanol. J. Pharmacol. Exp. Ther. 207:687–697.
Coon, M. J., A. H. Conney, R. W. Estabrook, H. V. Gelboin, J. R. Gillette, and P. J. O’Brien, eds. 1980. Microsomes, Drug Oxidations, and Chemical Carcinogenesis ,Volumes I and II. Academic Press, New York. 1258 pp.
De Matteis, F., and L. Cantoni. 1970. Alteration of the porphyrin nucleus of cytochrome P-450 caused in the liver by treatment with allyl-containing drugs. Is the modified porphyrin N-substituted? Biochem. J. 183:99–103.
Doull, J., C. D. Klaassen, and M. O. Amdur, eds. 1980. Toxicology, The Basic Science of Poisons ,2nd ed. Macmillan, New York.
Ehrenberg, L., S. Osterman-Golkar, D. Segerback, K. Svensson, and C. J. Calleman. 1977. Evaluation of genetic risks of alkylating agents. III. Alkylation of haemoglobin after metabolic conversion of ethylene oxide in vivo. Mutat. Res. 45:175–184.
Gibaldi, M., and D. Perrier. 1975. Pharmacokinetics. Marcel Dekker, New York. 329 pp.
Gillette, J. R. 1974a. A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. I. Correlation of changes in the covalent binding of reactive metabolite with changes in the incidence of severity of toxicity. Biochem. Pharmacol. 23:2785–2794.
Gillette, J. R. 1974b. A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. II. Alterations in the kinetics of covalent binding. Biochem. Pharmacol. 23:2927–2938.
Gillette, J. R. 1980. Pharmacokinetic factors governing the steady-state concentrations of foreign chemicals and their metabolites. Pp. 191–217 in Environmental Chemicals, Enzyme Function and Human Disease. Ciba Foundation Symposium 76, Excerpta Medica, Elsevier/North-Holland, Amsterdam.
Gillette, J. R., S. D. Nelson, G. J. Mulder, D. J. Jollow, J. R. Mitchell, L. R. Pohl, and J. A. Hinson. 1982. Formation of chemically reactive metabolites of phenacetin and acetominophen. Pp. 931–950 in R. Snyder, D. V. Parke, J. J. Kocsis, D. J. Jollow, C. G. Gibson, and C. M. Witmer, eds. Biologically Reactive Intermediates. II. Chemical Mechanisms and Biological Effects ,Part A. Plenum Press, New York.
Golkar, S. O. 1983. Tissue doses in man; implications in risk assessment. Dev. Toxicol. Environ. Sci. 11:289–298.
Gustafsson, J. A., J. Carlstedt-Duke, A. Mode, and J. Rafter, eds. 1980. Biochemistry, Biophysics and Regulation of Cytochrome P-450. Elsevier/North-Holland, Amsterdam.
Kappus, H., and H. Sies. 1981. Toxic drug effects associated with oxygen metabolism: Redox cycling and lipid peroxidation. Experientia 37:1233–1241.
Kato, R., and R. Sato, eds. 1982. Microsomes, Drug Oxidations and Drug Toxicity. Japan Scientific Societies Press, Tokyo.
Lau, S. S., T. J. Monks, K. E. Greene, and J. R. Gillete. 1984. Detection and half-life of bromobenzene-3,4-oxide in blood. Xenobiotica 14:539–543.
Mantel, N., and W. R. Bryan, 1961. “Safety” testing of carcinogenic agents. J. Natl. Cancer Inst. 27:455–470.
Ortiz de Montellano, P. R., B. A. Mico, and G. S. Yost. 1978. Suicidal activation of cytochrome P-450. Formation of a heme-substrate covalent adduct. Biochem. Biophys. Res. Commun. 83:1.
Singer, T., and R. Orndarza, eds. 1980. The Biochemical Basis of Drug Action. Elsevier/North-Holland, New York.
Snyder, R., D. V. Parke, J. J. Kocsis, D. J. Jollow, C. G. Gibson, and C. M. Witmer, eds. 1982. Bio logically Reactive Intermediates. II. Chemical Mechanisms and Biological Effects. Plenum Press, New York.
White, R. E., and M. J. Coon, 1980. Oxygen activation by cytochrome P-450. Annu. Rev. Biochem. 49:315–356.
Whittemore, A. S. 1978. Qualitative theories of oncogenesis. Adv. Cancer Res. 27:55–88.
Ziegler, D. M. 1978. Microsomal oxidases. Pp. 193–204 in S. Fleischer, Y. Hatafi, D. H. MacLennan, and A. Tzagoloff, eds. The Molecular Biology of Membranes. Plenum Press, New York.
Ziegler, D. M. 1980. Microsomal flavin-containing monooxygenase: Oxygenation of nucleophilic nitrogen and sulfur compounds. Pp. 201–227 in W. B. Jakoby, ed. Enzymatic Basis of Detoxication ,Volume 1. Academic Press, New York.
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© 1987 Plenum Press, New York
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Gillette, J.R., Estabrook, R.W. (1987). Evaluation of Xenobiotic Metabolism. In: Tardiff, R.G., Rodricks, J.V. (eds) Toxic Substances and Human Risk. Life Science Monographs. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-5290-7_16
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DOI: https://doi.org/10.1007/978-1-4684-5290-7_16
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