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Platelet-Activating Factor and Related Lipid Mediators pp 191–235Cite as

Conformational Properties of the PAF-Acether Receptor on Platelets Based on Structure—Activity Studies

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Abstract

A novel autacoid, platelet-activating factor (PAF, PAF-acether, AGEPC) is a phospholipid mediator with a wide range of biological activities (Pinckard et al., 1982; Snyder, 1985; Vargaftig et al., 1981). Identified as l-O-alkyl-2(R)-acetyl-glyc-ero-3-phosphocholine, 1, essentially composed of hexadecyl and octadecyl components, it was first described as a soluble component released from rabbit basophils sensitized with immunoglobulin E, which caused rabbit platelet aggregation (Ben-veniste et al., 1972). In other studies, a PAF-acether-like substance was isolated from the renal medulla and presented a potent hypotensive effect. It was named antihypertensive polar renomedullary lipid (APRL) (for review see Muirhead and Pitcock, 1985). An even more influential role in pathophysiological events has been attributed to PAF-acether, principally in anaphylaxis and shock, ever since the discovery of PAF-acether structure (Benveniste et al., 1979; Blank et al., 1979; Demopoulos et al., 1979) and its total synthesis (Godfroid et al., 1980). Figure 1 presents the relations between the membrane binding of PAF-acether and the subsequent cellular responses.

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Authors and Affiliations

  1. Henri Beaufour Institute, Le Plessis Robinson, France

    P. Braquet

  2. Laboratory of Molecular Pharmacochemistry, Faculty of Sciences, University of Paris 7, Paris, France

    J. J. Godfroid

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  1. P. Braquet
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  2. J. J. Godfroid
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  1. Medical and Health Sciences Division, Oak Ridge Associated Universities, Oak Ridge, Tennessee, 37831, USA

    Fred Snyder Ph.D

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© 1987 Plenum Press, New York

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Braquet, P., Godfroid, J.J. (1987). Conformational Properties of the PAF-Acether Receptor on Platelets Based on Structure—Activity Studies. In: Snyder, F. (eds) Platelet-Activating Factor and Related Lipid Mediators. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5284-6_9

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  • DOI: https://doi.org/10.1007/978-1-4684-5284-6_9

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