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The Chemical and Biological Properties of PAF Agonists, Antagonists, and Biosynthetic Inhibitors

  • Chapter
Platelet-Activating Factor and Related Lipid Mediators

Abstract

As PAF was being characterized as a highly potent lipid mediator of inflammation and anaphylaxis, its unusual structure stimulated considerable interest in the investigation of various structural analogs, initially to define the structure requirement for its biological actions, and later to explore the possibility of dissociating its cardiovascular, pulmonary, and renal activities. More recently, the possible existence of multimolecular species of PAF-like molecules in vivo is also being investigated.

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Author notes

  1. T. Y. Shen

    Present address: Chemistry Department, University of Virginia, Charlottesville, Virginia, 22901, USA

Authors and Affiliations

  1. Departments of Membrane and Arthritis Research and Biochemical Regulation, Merck, Sharp & Dohme Research Laboratories, Rahway, New Jersey, 07065, USA

    T. Y. Shen, San-Bao Hwang, Thomas W. Doebber & James C. Robbins

Authors
  1. T. Y. Shen
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  2. San-Bao Hwang
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  3. Thomas W. Doebber
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  4. James C. Robbins
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Editor information

Editors and Affiliations

  1. Medical and Health Sciences Division, Oak Ridge Associated Universities, Oak Ridge, Tennessee, 37831, USA

    Fred Snyder Ph.D

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© 1987 Plenum Press, New York

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Shen, T.Y., Hwang, SB., Doebber, T.W., Robbins, J.C. (1987). The Chemical and Biological Properties of PAF Agonists, Antagonists, and Biosynthetic Inhibitors. In: Snyder, F. (eds) Platelet-Activating Factor and Related Lipid Mediators. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5284-6_8

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  • DOI: https://doi.org/10.1007/978-1-4684-5284-6_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5286-0

  • Online ISBN: 978-1-4684-5284-6

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