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Platelet-Activating Factor and Related Lipid Mediators pp 89–113Cite as

Enzymatic Pathways for Platelet-Activating Factor, Related Alkyl Glycerolipids, and Their Precursors

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Abstract

The purpose of this chapter is to provide a succinct overview of the enzymatic reaction steps for alkyl glycerolipids and lipid precursors affiliated with the biosynthesis and catabolism of platelet-activating factor (PAF). Only the principal distinguishing features of the enzymes are summarized since detailed coverage of the metabolism of PAF (Lee and Snyder, 1985; Snyder, 1982, 1985a) and of ether lipids in general (Hajra, 1983; Horrocks and Sharma, 1982; Snyder, 1985b; Snyder et al., 1985a) has appeared in recent reviews or is discussed in other chapters of this book. This presentation is intended to serve as a quick and concise reference to the individual enzymatic reactions involving PAF and related ether-linked lipids. A composite pathway that illustrates the interrelationship of these reaction steps is also included.

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Abbreviations

DTT:

dithiothreitol

PAF:

platelet-activating factor l-alkyl-2-acetyl-sn-glycero-3-phosphocholine

DHAP:

dihydroxyacetone-P

DHA:

dihydroxyacetone

SHR:

spontaneous hypertensive rat

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  1. Medical and Health Sciences Division, Oak Ridge Associated Universities, Oak Ridge, Tennessee, 37831, USA

    Fred Snyder

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  1. Medical and Health Sciences Division, Oak Ridge Associated Universities, Oak Ridge, Tennessee, 37831, USA

    Fred Snyder Ph.D

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© 1987 Plenum Press, New York

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Snyder, F. (1987). Enzymatic Pathways for Platelet-Activating Factor, Related Alkyl Glycerolipids, and Their Precursors. In: Snyder, F. (eds) Platelet-Activating Factor and Related Lipid Mediators. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5284-6_5

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